نتایج جستجو برای: genetic association
تعداد نتایج: 1059533 فیلتر نتایج به سال:
Epidemiological and genetic association studies show that genetics play an important role in the attainment of education. Here, we investigate the effect of this genetic component on the reproductive history of 109,120 Icelanders and the consequent impact on the gene pool over time. We show that an educational attainment polygenic score, POLYEDU, constructed from results of a recent study is as...
there are much heterogeneity in the genetic variation of type 2 diabetes (t2d). the purpose of this study was to investigate the association of seven novel genetic loci identified in a recent genome-wide association studies (gwas) with t2d in chinese dong populations.a case-controlled study was performed in individuals of chinese dong nationality. the genotypes of pard3b (rs849230), loc729993 (...
Background and Purpose—A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported. Summary of Review—The skantness of replicable associations partly relates to poor study design. Important methodological considerations include adequate sample size, the selection of appropriate co...
results findings showed that the genotype -607a/a is associated with the susceptibility to chronic hepatitis b. furthermore, allele c at position -137 is suggested to play a protective role against development of chronic hbv infection. conclusions host genetic factors play an important role in determining the outcome of hbv infection. it is suggested that il-18 genotype -607 a/a is associated w...
conclusions the results of the study show no significant association between norepinephrine transporter polymorphism scl6a2 and adhd. results the percentages of adhd subtypes for combined, inattentive, and hyperactive/impulsive were 72.2%, 17.2%, and 11.9%, respectively. there was no significant association between norepinephrine transporter polymorphism and adhd (p = 0.81). moreover, no signif...
The heading date is a vital factor in achieving a full rice yield. Cultivars with particular flowering behaviors have been artificially selected to survive in the long-day and low-temperature conditions of Northeast China. To dissect the genetic mechanism responsible for heading date in rice populations from Northeast China, association mapping was performed to identify major controlling loci. ...
We present a coherent Bayesian framework for selection of the most likely model from the five genetic models (genotypic, additive, dominant, co-dominant, and recessive) commonly used in genetic association studies. The approach uses a polynomial parameterization of genetic data to simultaneously fit the five models and save computations. We provide a closed-form expression of the marginal likel...
In genetic association studies, due to the varying underlying genetic models, no single statistical test can be the most powerful test under all situations. Current studies show that if the underlying genetic models are known, trend-based tests, which outperform the classical Pearson χ² test, can be constructed. However, when the underlying genetic models are unknown, the χ² test is usually mor...
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