A “generation” is a classification marking an advance in pharmaceutical development within a class of agents. With respect to antibiotics, a modifi cation in chemical structure, a twist in the mechanism of action, a shift or expansion of antimicrobial activity, improved effi cacy, lower resistance, better tolerability, altered pharmacokinetics, or some combination of the above, may solve a prob...

OBJECTIVE To study the in-vitro antimicrobial activity of Cefpirome: A new fourth generation Cephalosporin in comparison with other agents against clinically significant Gram-negative and Gram-positive bacteria. SETTING A multi-center in-vitro study was conducted in 13 centers. MATERIALS AND METHODS Bacterial isolates--A total of 1300 isolates were collected from different clinical laborato...

The present study aims to detect the production of extended-spectrum beta-lactamases (ESBL) by enterobacteria isolated from samples of fresh shrimp and fish obtained from the retail trade of the city of Sobral, Ceará State, Brazil. All bacterial isolates were submitted to identification and antimicrobial susceptibility testing using aminopenicillin, beta-lactamase inhibitors, carbapenem, 1st, 2...

ObjectiveAntibiotics are frequently prescribed for the treatment of acute lower respiratory infections (ALRI) in children ≤5 years age, even though viral aetiologies most common. The aim this study was to describe antibiotic prescribing rates and patterns age hospitalized with ALRI.MethodsA retrospective conducted involving patients aged 1 month 5 ALRI at a university hospital. Patient demograp...

Article history: Received on: 27/07/2016 Revised on: 24/08/2016 Accepted on: 30/09/2016 Available online: 28/12/2016 Beta lactam antibiotics are one of the most commonly prescribed antibiotic drug classes in medical practice. Cephalosporins differ from other beta lactam antibiotics in both their structure and spectrum of action. Beta lactam antibiotics, in general, may cause platelet deficiency...

Ceftriaxone is a third-generation of cephalosporins which is used for community acquired infections such as pneumonia and urinaly tract infections. It showed great advantage of once-daily administration based on pharmacological manner and need no renal impairment. It is stable for β-lactamases against firstor secondgenerations of cephalosporins. Ceftriaxone is also used for streptococcal endoca...

Methicillin-resistant Staphylococcus aureus (MRSA) are bacteria, responsible for severe and hard-to-manage infections in human. They are resistant to beta-lactam antibiotics penicillins (methicillin, dicloxacillin, nafcillin, and oxacillin), cephalosporins and carbapenems, but can also be resistant to the new-generation MRSA-active cephalosporins (such as ceftaroline) or other groups of antibio...

Salmonella enterica is recognized as one of the major food-borne pathogens with more than 2,500 serotypesworldwide. The present study addresses antimicrobial resistance of Salmonella enterica serovar Enteritidisisolates in Iran. A collection of 151 Salmonella spp. isolates collected from poultry were serotyped toidentify Salmonella Enteritidis. Sixty-one Salmonella Enteritidis were subsequently...

Salmonella enterica serotypes are one of the most important food borne pathogens and significant public health concerns around the world in humans and other animal species. A total of eighty three epidemiologically unrelated clinical isolates of Salmonella enterica serovars were subjected to antimicrobial susceptibility testing. Eleven isolates (13.1%) which were resistant to at least 4 groups ...