Helix-hairpin-helix (HhH) is a widespread motif involved in non-sequence-specific DNA binding. The majority of HhH motifs function as DNA-binding modules, however, some of them are used to mediate protein-protein interactions or have acquired enzymatic activity by incorporating catalytic residues (DNA glycosylases). From sequence and structural analysis of HhH-containing proteins we conclude th...

Although previous studies are beginning to point to the specific types of helix-helix interactions that stabilize the folds of membrane-bound helical proteins, quantitative thermodynamic data on natural membrane proteins has been very limited. Here the database is expanded substantially by adding thermodynamic data for a series of sequence variants of M2 protein from influenza A virus. The M2 p...

Protein fold recognition is an important step towards understanding protein three-dimensional structures and their functions. A conditional graphical model, i.e., segmentation conditional random fields (SCRFs), is proposed as an effective solution to this problem. In contrast to traditional graphical models, such as the hidden Markov model (HMM), SCRFs follow a discriminative approach. Therefor...

The tourism sector is one of the sectors that has been severely affected during Covid-19 pandemic, especially marine in Indonesia. In this work, a case study West Sulawesi region Indonesia was used to conduct qualitative reanalysis which raises concerns about sustainability existing area. This study, general, aims get answers on strategies areas prioritize as their main income, using strategy o...

The wide variety of available mobile devices, associated with the increase in wireless communication network availability, enables an increasing offer and ubiquitous technologies. In this sense, article proposes approach called Helix-SIoT, which explores Social Internet Things concepts to support Blind People (BP). objective is enhance treatment different sensors that integrate assistance these...

The ligand-binding domains of steroid hormone receptors possess a conserved structure with 12 alpha-helices surrounding a central hydrophobic core. On agonist binding, a repositioned helix 12 forms a pocket with helix 3 (H3) and helix 5 (H5), where transcriptional coactivators bind. The precise molecular interactions responsible for activation of these receptors remain to be elucidated. We prev...