N6-methyladenosine (m6A) RNA modification is the most abundant method in mRNA, and it plays an important role occurrence development of many cancers. This paper mainly discusses m6A methylation regulators lung adenocarcinoma (LUAD) to identify novel prognostic biomarkers. The gene expression data 19 LUAD patients its relevant clinical parameters were extracted from Cancer Genome Atlas (TCGA) da...

BACKGROUND Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic variables are incomplete for prognosis prediction. METHODS To improve the classification of adult patients diagnosed with B-ALL into prognosis groups, two strategies were examine...

Accumulating evidence has shown that aberrant lncRNA expression plays an oncogenic or tumor-suppressive role in the tumorigenesis of laryngeal cancer. However, the prognostic roles of lncRNAs in laryngeal cancer recurrence are still poorly understood. In this study, we obtained lncRNA expression profiles of 109 patients with laryngeal cancer by mining previously published gene expression microa...

BACKGROUND Microarray technology enables a standardized, objective assessment of oncological diagnosis and prognosis. However, such studies are typically specific to certain cancer types, and the results have limited use due to inadequate validation in large patient cohorts. Discovery of genes commonly regulated in cancer may have an important implication in understanding the common molecular m...

Current staging is inadequate for predicting clinical outcome of esophageal squamous cell carcinoma (ESCC). Aberrant expression of LOXL2 and actin-related proteins plays important roles in ESCC. Here, we aimed to develop a novel molecular signature that exceeds the power of the current staging system in predicting ESCC prognosis. We found that LOXL2 colocalized with filamentous actin in ESCC ce...

Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors (PBT) that may lead to novel therapeutic strategies. Participants the cohort Pediatric Brain Tumor Atlas: CBTTC (CBTTC cohort), were randomly divided training validation cohorts. In cohort, Kaplan-Meier analysis univariate Cox regression model applied preliminary screening prognostic ...

Professor WH van Harten MD ment [2]. In 2002, researchers at the Netherlands Cancer Institute (NKI, Amsterdam, the Netherlands) identified a 70-gene prognosis signature (MammaPrintTM), using microarray analysis for lymph node-negative breast cancer patients [3]. Using the 70-gene signature, the selection of patients that will benefit most from adjuvant systemic treatment could be more accurate....

BACKGROUND We are investigating the molecular basis of melanoma by defining genomic characteristics that correlate with tumour phenotype in a novel panel of metastatic melanoma cell lines. The aim of this study is to identify new prognostic markers and therapeutic targets that might aid clinical cancer diagnosis and management. PRINCIPAL FINDINGS Global transcript profiling identified a signa...

BACKGROUND Many long non-coding RNAs(lncRNAs) have been found to be a good marker for several tumors. Using lncRNA-mining approach, we aimed to identify lncRNA expression signature that can predict breast cancer patient survival. METHODS We performed LncRNA expression profiling in 887 breast cancer patients from Gene Expression Omnibus (GEO) datasets. The association between lncRNA signature ...

Long noncoding RNAs (lncRNAs) have emerged as essential players in gene regulation. An ever-increasing number of lncRNAs has been found to be associated with the biogenesis and prognosis of gastric cancer (GC). We aimed to develop an lncRNA signature with prognostic value for survival outcomes of GC. Using an lncRNA mining approach, we analyzed the lncRNA expression profiles of 492 GC patients ...