The expression of the placental growth factor (PGF) in cancer cells and tumor microenvironment can contribute to induction angiogenesis, supporting cell metabolism by ensuring an adequate blood supply. Angiogenesis is a key component as it facilitates delivery nutrients oxygen rapidly growing cells. PGF recognized novel target for anti-cancer treatment due its ability overcome resistance existi...

SET and MYND domain-containing protein 2 (SMYD2) is a lysine methyltransferases (PKMTs) from family SMYD. It can regulate gene transcription by catalysing the methylation of residues substrates that play significant role in oncogenesis. Inhibition SMYD2 could lead to proposal new drugs for cancers, where it involved. In this study, structure-based virtual screening was carried out identificatio...

Lung cancer is the second most frequent worldwide diagnosed cancer. Mutations in RAS genes family are among common oncogenic alterations occurring non-small cell lung (NSCLC). Many treatment options against KRAS mutations have been developed for NSCLC; however, they remain insufficient. Moreover, role of and HRAS gene expression remains unclear. However, inhibitors seem to be a good candidate n...

Abstract Despite initial responsiveness to standard treatments like radiation and chemotherapy, IDH mutant gliomas inevitably recur, become more clinically aggressive, lead untimely death. The aggressive change in clinical outcome is driven by insensitivity conventional methods of treatment, necessitating an improved therapeutic strategy at this stage the disease. Greater than 20% recurrent exh...

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter gene expression globally and thus affect memory processes in a nonspecific manner. Here, we show that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors ...

The genetic defect in Friedreich's ataxia (FRDA) is the hyperexpansion of a GAA•TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Histone post-translational modifications near the expanded repeats are consistent with heterochromatin formation and consequent FXN gene silencing. Using a newly developed human neuronal cell model, derived from p...

The MLL gene located at l lq23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute leukemias. Recently, it has become apparent that the MLL gene is very frequently disrupted by chromosomal translocations in patients with secondary leukemias associated with chemotherapeutic regimens incorporating topoisomerase II inhibitors. These secondary leukemias ...

About half of human cancers show normal TP53 gene and aberrant overexpression of Mdm2 and/or MdmX. This fact promotes a promising cancer therapeutic strategy which targeting the interactions between p53 and Mdm2/MdmX. For developing the inhibitors to disrupt the p53Mdm2/MdmX interactions, we systematically investigate structural and interaction characteristics of p53 and inhibitors with Mdm2 an...

Activating mutations and fusions of the ALK oncogene have been identified as drivers in a number malignancies. Crizotinib subsequent tyrosine kinase inhibitors improved treatment outcomes for these patients. In this paper, we discuss case an adolescent patient with acute myeloid leukemia, who was to activating fusion, which is rare finding has never reported cases AML without monosomy 7. added ...

Background: Cervical cancer is the second most common female cancer worldwide. Inhibitors of apoptosis proteins (IAPs) block apoptosis; therefore, therapeutic strategies targeting IAPs have attracted the interest of researchers in recent years. Apollon, a member of IAPs, inhibits apoptosis and cell death. RNA interference is a pathway in which small interfering RNA (siRNA) or shRNA (short hairp...