BACKGROUND The prevalence of smoking in the United States has been closely monitored. However, little is known about the epidemiology of nicotine dependence. We studied DSM-III-R nicotine dependence in the United States, trends across cohorts, and the role of nicotine dependence in smoking persistence. METHODS The Tobacco Supplement to the National Comorbidity Survey was administered to a rep...

We apply the Tremaine-Weinberg method of pattern speed determination to data cubes of CO emission in six spiral galaxies from the BIMA SONG survey each with an ISM dominated by molecular gas. We compare derived pattern speeds with estimates based on other methods, usually involving the identification of a predicted behavior at one or more resonances of the pattern(s). In two cases (NGC 1068 and...

PURPOSE To evaluate the antifungal activity of amphotericin B (AmB) in a mouse model of systemic candidiasis following administration of a novel oral AmB formulation (iCo-010) that has been pre-exposed to tropical temperatures. METHODS Amphotericin B (AmB) was prepared as a 5 mg/mL dispersion in a mixture of Peceol, Gelucire 44/14 and VitE-TPGS 2,3 (iCo-010). The formulation was protected fro...

OBJECTIVE To assess trends in the prevalence and social distribution of child stunting in Brazil to evaluate the effect of income and basic service redistribution policies implemented in that country in the recent past. METHODS The prevalence of stunting (height-for-age z score below -2 using the Child Growth Standards of the World Health Organization) among children aged less than 5 years wa...

Objective To quantify psychological distress experienced by emergency, anaesthetic and intensive care doctors during the acceleration phase of COVID-19 in UK Ireland. Methods Initial cross-sectional electronic survey distributed first pandemic wave Ireland (UK: 18 March 2020–26 2020 Ireland: 25 2020–2 April 2020). Surveys were via established specialty research networks, within a three-part lon...

The perinucleolar compartment (PNC) is a unique nuclear structure localized at the periphery of the nucleolus. Several small RNAs transcribed by RNA polymerase III and two hnRNP proteins have been localized in the PNC (Ghetti, A., S. Piñol-Roma, W.M. Michael, C. Morandi, and G. Dreyfuss. 1992. Nucleic Acids Res. 20:3671-3678; Matera, A.G., M.R. Frey, K. Margelot, and S.L. Wolin. 1995. J. Cell B...

BACKGROUND Despite the evidence supporting the importance of early beta-blocker therapy, this intervention has received little attention as an indicator of quality of care. OBJECTIVES To determine how often beta-blockers are administered as early treatment of acute myocardial infarction in patients 65 years of age or older, to identify predictors of the decision to use beta-blockers, and to e...

BACKGROUND School-located influenza vaccination (SLV) programs have the potential to mass-vaccinate all enrolled children, but parental consent is required. OBJECTIVE To examine parental attitudes and determine predictors of parental consent for vaccination of schoolchildren through SLV programs. PATIENTS/METHODS Surveys were distributed to parents of 4517 children during 2009-2010 (year 1)...