نتایج جستجو برای: gdf
تعداد نتایج: 823 فیلتر نتایج به سال:
Among the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk. The concentrations of inflammatory biomarkers, however, are influenced, among others, by physiological variations, which are the natural, within-individual variation oc...
Objective: Growth / Differentiation Factor-5 (GDF-5) is a member of the family of Bone Morphogenetic Proteins (BMPs) known to have diverse effects on musculoskeletal connective tissues [1,2]. Recently, biomechanical and ultrastructural abnormalities have been demonstrated in several collagen-rich tissues from GDF-5 deficient mice, including Achilles tendon, tail tendon, and long bone [3-5]. In ...
Let G = (V, E) be a graph. A function g : V → [0, 1] is called a global dominating function (GDF ) of G, if for every v ∈ V, g(N [v]) = ∑ u∈N [v] g(u) ≥ 1 and g(N(v)) = ∑ u/ ∈N(v) g(u) ≥ 1. A GDF g of a graph G is called minimal (MGDF ) if for all functions f : V → [0, 1] such that f ≤ g and f(v) 6= g(v) for at least one v ∈ V , f is not a GDF . The fractional global domination number γfg(G) is...
PURPOSE The study objective was to investigate and validate plasma growth differentiation factor-15 (GDF-15) as a predictor of lymph node metastasis and a poor prognosis in primary endometrial cancer. EXPERIMENTAL DESIGN Plasma samples from 510 women treated for endometrial cancer in a primary investigation cohort (n = 44) and a secondary validation cohort (n = 466) were analyzed for GDF-15. ...
BACKGROUND Growth differentiation factor-15 (GDF-15), a biomarker associated with remodeling, oxidative stress and inflammation, has been used to stratify heart failure (HF) patients. However, its prognostic value in Chinese HF patients is still unknown. METHODS GDF-15 levels were examined on admission in 272 consecutive HF patients in Beijing Hospital (a Chinese tertiary medical center) by a...
BACKGROUND Inflammation and neovascularization play critical roles in the stability of atherosclerotic plaques. Whole-body quantitative assessment of these plaque features may improve patient risk-stratification for life-threatening thromboembolic events and direct appropriate intervention. In this report, we determined the utility of the MR contrast agent gadofluorine-M (GdF) for staging plaqu...
Blood levels of growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), have been associated with various pathological processes and diseases, including cardiovascular disease and cancer. Prior studies suggest genetic factors play a role in regulating blood MIC-1/GDF-15 concentration. In the current study, we conducted the largest genome-wide associati...
Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not present in either Gdf1-/- or Nodal+/- single mutants, including absence of notochord...
The present study was designed to evaluate the role of growth differentiation factor-5 (GDF-5) and bone morphogenetic protein type II receptor (BMPR-II) in the development of lumbar intervertebral disc degeneration (IDD). A total of 24 patients with lumbar IDD (experiment group) and 6 patients with lumbar vertebral fracture (control group) were enrolled in the study. Tissue samples of IVD from ...
Purpose: The study objective was to investigate and validate plasma growth differentiation factor-15 (GDF-15) as a predictor of lymph node metastasis and a poor prognosis in primary endometrial cancer. Experimental Design: Plasma samples from 510 women treated for endometrial cancer in a primary investigation cohort (n 1⁄4 44) and a secondary validation cohort (n 1⁄4 466) were analyzed for GDF-...
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