Simvastatin (SIM)-induced myopathy is a dose-dependent adverse drug reaction (ADR) that has been reported to occur in 18.2% of patients receiving a 40- to 80-mg dose. The pharmacokinetics of SIM hydroxy acid (SIMA), the bioactive form of SIM, and the occurrence of SIM-induced myopathy are linked to the function of the organic anion transporting polypeptide (Oatp) hepatic uptake transporters. Ge...

Structured illumination microscopy (SIM) has been widely used in life science imaging applications. The maximum resolution improvement of SIM, compared to conventional bright field system is a factor of 2. Here we present an approach to structured illumination microscopy using the proximity projection grating scheme (PPGS), which has the ability to further enhance the SIM resolution without inv...

Our previous study demonstrated that oral treatment with simvastatin (SIM) suppressed renal sympathetic nerve activity (RSNA) in the rabbits with chronic heart failure (CHF). The purpose of this experiment was to determine the effects of direct application of SIM to the central nervous system on RSNA and its relevant mechanisms. Experiments were carried out on 21 male New Zealand White rabbits ...

Most state-of-the-art global climate models (GCMs) project an increase in atmospheric poleward energy transport with global warming; however, the amount of increase varies significantly from model to model. Using an energy balance model that diffuses moist static energy, it is shown that: (1) the increase in atmospheric moisture content causes most of the increase in transport, and (2) changes ...

This letter reports a study on some topological properties of chaos using a generalized competitive mode (GCM). The Lorenz system and the Chen system are used as examples for comparison. It is shown that for typical parameter values used in the two systems, the Lorenz attractor has one pair of GCMs in competition, while the Chen attractor has two pairs of GCMs in competition. This explains why ...

Article history: Received on: 19/11/2013 Revised on: 10/12/2013 Accepted on: 05/03/2013 Available online: 27/04/2014 The neuropharmacological activity of different doses (100, 200, 400 mg/kg/p.o.) of petroleum ether (SIP), methanolic (SIM) and aqueous extract (SIA) obtained from Sphaeranthus indicus Linn were studied in mice. Sphaeranthus indicus was evaluated for its effect on motor coordinati...

Background: Therapeutic utilities of doxorubicin (DOX), an anticancer anthracycline antibiotic, are limited by its serious dosedependent toxicity to non-target tissues such as testis. The aim of the present study was to elucidate the potential of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, to attenuate DOX-induced spermatotoxicity in male mice. M...

The embryonic neuroepithelium of Drosophila gives rise to the central nervous system. We have studied the mutant phenotype and expression of a gene, single-minded (sim), which is involved in generating a specific region of this neuroepithelium. In sim mutant embryos, a subset of neuronal and nonneuronal precursor cells lying along the midline fail to emerge with the rest of the neuroepithelium....