several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine which bi...

Objective: The objective of the present work was to formulate a gastroretentive dosage form of Valacyclovir, an anti viral drug. Methods: Valacyclovir gastroretentive mucoadhesive tablets were prepared using polymers such as Carbopol 974P and hydroxy propyl methyl cellulose (HPMC) K4M, in different proportions by wet granulation technique. Compatibility studies were performed by FTIR spectrosco...

in the long-term management of ulcerative colitis patients, repeat dosing maybe required. since 5-asa is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. the aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-asa deliver...

conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

The oral route is the best and most popular for administration of drugs in systemic circulation. There are number which given through route. Gastro-retentive drug delivery system very important system. gastro-retentive prolonged time git also improve their bioavailability. These widely used site specific treatment disorders diseases. approaches gastro retentive such as floating system, mucoadhe...

Gastroretentive drug delivery system i.e. floating microspheres of an H2 receptor antagonist drug ‘famotidine’ was successfully prepared using combination of polymer as hydroxyl propyl ethyl cellulose K15M (HPMC K15M) and cellulose acetate via non-aqueous solvent evaporation (oil-in-water) technique. Famotidine loaded floating microsphere formulations were prepared by dissolving polymer in solv...