Endoscopic resection has been performed to treat small gastric neoplasms. However, this technique for small gastric gastrointestinal stromal tumors (GISTs) remains controversial. This study aims to compare the safety and surgical outcomes of endoscopic versus open resection of small gastric GISTs.The medical records of 54 consecutive gastric GISTs patients with tumor size of ≤2 cm, who were sur...

Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, Xray powder diffraction (XRD) and Scanning electron micro...

The objective of this work was to study the gastric emptying (GE) of liquids in fasted and sucrose-fed rats with toxic hepatitis induced by acetaminophen. The GE of three test meals (saline, glucose and mayonnaise) was evaluated in Wistar rats. For each meal, the animals were divided into two groups (N = 24 each). Group I was fed a sucrose diet throughout the experiment (66 h) while group II wa...

In the past twenty years evidence has accumulated that liquorice and related compounds accelerate the rate of healing of gastric ulcers. Powdered succus liquiritiae (Revers, 1948) and glycyrrhiza extract (Schulze, Franke, and Keller, 1954; Ferenbach, 1954; Ohrt, 1955) were shown to be beneficial in patients with gastric ulcer but adequately controlled clinical trials of liquorice extracts were ...

Efforts to define gender- and ethnic-dependent differences in ethanol first-pass metabolism by gastric mucosa and liver have been limited by a lack of analytical tools that distinguish ethanol concurrently administered by oral and intravenous routes. A stable isotope gas chromatography-mass spectrometry method for simultaneous measurement of ethanol and ethyl-d5 alcohol in serum was developed t...

Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to ...

Eudragit E 100 and polycaprolactone (PCL) floating microspheres for enhanced gastric retention and drug release were successfully prepared by oil in water solvent evaporation method. Metronidazole benzoate, an anti-protozoal drug, was used as a model drug. Polyvinyl alcohol was used as an emulsifier. The prepared microspheres were observed for % recovery, % degree of hydration, % water uptake, ...

BACKGROUND/AIM The Gastroparesis Cardinal Symptom Index (GCSI) was developed to assess symptoms of gastroparesis. The aim of this study was to correlate symptoms using the GCSI with delayed gastric emptying (DGE) in symptomatic patients referred for gastric emptying scintigraphy (GES). METHODS A total of 226 consecutive symptomatic patients referred for GES completed the 9-question GCSI. GES ...

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailabili...

BACKGROUND The histopathology of the gastric mucosa in patients with gastroparesis, a condition characterized by gastric retention without obstruction, has not been described. AIM To test the hypothesis that reactive gastropathy is more common in patients with gastroparesis than in subjects with normal gastric motility. METHODS We compared the prevalence of reactive gastropathy, Helicobacte...