Objective. To report the institutional experience of evolution duodenum-preserving pancreatic head resection (DPPHR) as a surgical treatment for chronic pancreatitis with an inflammatory tumor well cystic and benign, premalignant neoplasms neuroendocrine tumors head. Methods. DPPHR is associated preservation gastric antrum, common bile duct duodenum/upper jejunal loop, contrary to Kausch-Whippl...

Gastric cancer is one of the most widespread cancers and makes a significant contribution to global mortality rate from malignant neoplasms. The late onset clinical symptoms main reason why disease often diagnosed at an advanced stage, this limits available therapeutic approaches. Despite fact, that extensive studies have been carried out identify mechanisms markers development progression dise...

BACKGROUND With term GIST is now defined a group of mesenchimal tumours of the gastrointestinal tract expressing immunopositivity for kit protein kinase (CD117). Surgical therapy remains the gold standard for these rare tumours. Imatinib Mesylate (STI-571) is a potent inhibitor of Kit Kinase activity and different reports demonstrated its efficacy in unresectable or metastatic Gists. AIM OF T...

In 1899, only four years after Roentgen's discovery, Francis H. Williams, assisted by Walter B. Cannon, examined, by means of roentgen rays, the stomachs of two children who had been given bismuth meals. The observations, which were described in detail in Williams' book, pertained chiefly to variations in size, form, and position of the stomach during the process of digestion, but in his final ...

The present study is the first to evaluate the expression and activity of MnSOD, Cu/ZnSOD and catalase in human gastric samples, since ROS play a significant role in the pathogenesis of different forms of malignancy inducing mutations and various diseases such as gastric cancer. Biopsies and surgical samples from 53 patients (male/female 22/31, mean age 56.5+/-15.8 years) consisted of 15 health...

BACKGROUND AND STUDY AIM The risk of bleeding after endoscopic submucosal dissection (ESD) in patients with early gastric neoplasms who do not discontinue aspirin for the procedure has not been established. We aimed to investigate whether post-ESD gastric bleeding is increased in patients who take aspirin. PATIENTS AND METHODS Patients who underwent ESD for early gastric neoplasms at the Nati...

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Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression...

BACKGROUND AND STUDY AIMS  Combined use of thienopyridine derivatives and other antithrombotic agents is reported to be a risk factor for postoperative bleeding after gastric endoscopic submucosal dissection (ESD). However, risk associated with a single thienopyridine derivative has not been evaluated. In this study, we aimed to evaluate bleeding risks of gastric ESD without discontinuation of ...