Abstract BACKGROUND We previously reported on our in vitro and vivo studies using the metallocompound gallium maltolate (GaM) to target glioblastoma (GBM). demonstrated a profound cytotoxic effect vitrov vivo. Additionally, preliminary data suggested substantial inhibitory tumor growth, as well significant extension of disease-specific survival (OS). Here, we further validate effects GaM METHOD...

Skeletal muscle and liver tissue from 0,-day-old chick embryos were dissociated into separate cells using 0-25 % (w/v) crude trypsin. The effect of rabbit anti-actomyosin sera on the aggregation of these cells was estimated by the gyratory shaker and turbidimetric methods. Studies were also undertaken on the ability of fluorescein isothiocyanate-labelled rabbit anti-uterine actomyosin serum (FI...

BACKGROUND The humanitarian response to the crisis in Darfur is the largest humanitarian operation in the world. To investigate the evolution of the conditions of the affected population, we analysed trends in malnutrition and mortality, the most widely accepted indicators for assessing the degree of severity of a crisis. METHODS We did a meta-analysis of 164 publicly available surveys taking...

Prostaglandin E2 (PGE2) was found to bind specifically to a 100,000 x g pellet prepared from bovine adrenal medulla. The PGE receptor was associated with a GTP-binding protein (G-protein) and could be covalently cross-linked with this G-protein by dithiobis(succinimidyl propionate) in the 100,000 x g pellet (Negishi, M., Ito, S., Tanaka, T., Yokohama, H., Hayashi, H., Katada, T., Ui, M., and Ha...

BACKGROUND Environmental exposure may play an important role in the incidences of neural tube defects (NTD) of birth defects. Their influence on NTD may likely be non-linear; few studies have considered spatial autocorrelation of residuals in the estimation of NTD risk. We aimed to develop a spatial model based on generalized additive model (GAM) plus cokriging to examine and model the expected...

Incorporating ecological information into image-based vegetation mapping remains a challenge. Much attention has been placed on the use of ancillary information layers in image classification (e.g. slope, aspect, elevation) in that they provide indirect links to information that is ecologically relevant to species distributions. The objective of this study was to assess the utility of incorpora...

Experimental results on the connection between meanE×B flows and coherent oscillations at the frequency of the geodesic acoustic mode (GAM) in the H-1 heliac are presented. An increase in the mean local radial electric field, Er , is correlated with the development of several coherent modes. As mean Er increases, spectral energy, which is mostly contained in coherent modes, grows. This is follo...

This paper reviews various global instabilities destabilized by tangential neutral beam injection (NBI) in the Large Helical Device (LHD) plasmas. These global modes are toroidal Alfvén eigenmodes (TAEs), which are also observed in tokamak plasmas, and helicity-induced Alfvén eigenmodes (HAEs) which are observed only in three-dimensional plasmas such as LHD plasmas. Moreover, reversed magnetic ...