Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities these polysaccharides have been extensively studied. derivatives obtained by sulfation, complexation, phosphorylation most studied biological properties galactomannans. shown several pharmacological activities such as antiviral, antimicrob...

Abstract The consensus definitions of invasive fungal diseases from the EORTC/MSGERC were recently revised and updated. They now include cutoff values for galactomannan test that support diagnosis probable aspergillosis. In this supplement article, we provide a rationale these proposed thresholds based on test’s characteristics performance in different patient populations specimen types.

Background : Detection of biomarkers, such as galactomannan (GM), has proven to be great significance in early recognition invasive aspergillosis (IA). The aim our study was evaluate the lateral flow assay (LFA) for detection GM on serum and bronchoalveolar lavage (BAL) samples previously positive by enzyme-linked immunosorbent (ELISA). Methods: performed BAL obtained from patients with suspect...

Aspergillus galactomannan antigenemia is an accepted tool for the diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Little known, however, about utility this biomarker to assess efficacy antifungal therapies. The pharmacokinetics (PK) and pharmacodynamics (PD) posaconazole treatment prophylaxis were investigated persistently rabbit model fumigatus IPA at doses between...

The extraction of polysaccharides by autohydrolysis of spent coffee grounds (SCG) was studied. Experimental assays were performed using different temperatures (160-200°C), liquid/solid ratios (5-15ml water/g SCG) and extraction times (10-50min) in order to determine the conditions that maximize the extraction of polysaccharides with high antioxidant activity. Autohydrolysis was demonstrated to ...

A new mathematical model based on Michaelis Menten (MM) kinetics is developed to predict the changes in molecular weight distribution (MWD) during the enzymatic depolymerization of guar galactomannan. The model accounts for the effect of branching by considering the guar molecule as a substrate having three types of bonds with different MM kinetic parameters. The overall kinetics of the enzymat...