introduction: tonsillectomy is one of the most common surgeries performed worldwide. post-operative pain arising from tonsillectomy is one of the earliest complications that can postpone oral nutrition and increase the hospitalization period. administration of opioids via injection is usually preferred to relive pain in these patients. however, the side effects of this approach prompted us to s...

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hyd...

Research data show that diuretics can have anticonvulsant properties. This study examined effects of ethacrynic acid, a loop diuretic, and hydrochlorothiazide, a thiazide-type diuretic, on the anticonvulsant activity of gabapentin, a newer antiepileptic drug, in the maximal electroshock seizure threshold test in mice. Diuretics were administered intraperitoneally (ip.) both acutely (single dose...

OBJECTIVES Neuropathic pain is caused by lesions or diseases affecting the somatosensory system and often responds poorly to typical medications. In this study, we evaluated anti-nociceptive effects of morphine, gabapentin and their combination on heat hyperalgesia, cold and mechanical allodynia in chronic constriction injury (CCI) model of neuropathic pain in rats. MATERIALS AND METHODS Morp...

Introduction. Gabapentin is a recently introduced antiepileptic drug [l]. Gabapentin is now widely prescribed for the management of neuropathic pain [2]. Designed to mimic GABA, its mechanism c! action remains elusive [3]. Daily use of gabapentin is associated with above normal occipital lobe GABA in those patients whose seizure control improved [4, 51. Vigabatrin is one of the most potent of t...

Gabapentin is an anticonvulsant widely used in the treatment of epilepsy. No peculiar chromophore is available on the gabapentin moiety for direct analysis by absorption spectrophotometry. A sensitive spectrophotometric method for the determination of gabapentin in bulk, pharmaceutical formulations and human plasma has been developed. In this method, gabapentin directly derivatized with vanilli...

Gabapentin is an anticonvulsant widely used in the treatment of epilepsy.A simple, rapid, accurate, precise and economic spectrofluorimetric methods have been developed for the estimation of gabapentin in pharmaceutical formulations and in spiked human plasma. The analysis and validation dine by using SHIMADZU RF – 5301 Spectofluorimeter, equipped with Xenon arc lamp, using quartz cell (1×1×4.5...

CONTEXT Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies. OBJECTIVE To evaluate the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy. DESIGN Randomized, double-blind, placebo-controlled, 8-week trial conducted between July 1996 and March 1997. SETT...

BACKGROUND Anticonvulsants and antidepressants are mostly used in management of painful diabetic neuropathy (PDN). However there are few direct comparisons between drugs of these classes, making evidence-based decision-making in the treatment of painful diabetic neuropathy difficult. OBJECTIVES This study aimed to perform a network meta-analysis and benefit-risk analysis to evaluate the compa...

a varieties of medications have been suggested to prevent hemodynamic instabilities following laryngoscopy and endotracheal intubation. this study was conducted to determine the beneficial effects of gabapentin on preventing hemodynamic instabilities associated with intubation in patients who were a candidate for coronary artery bypass surgery (cabg). this double blinded randomized, parallel gr...