The intercalated paracapsular cells (pcs) are small GABAergic interneurons that form densely populated clusters surrounding the basolateral (BLA) complex of the amygdala. Their main task in the amygdala circuitry appears to be the control of information flow, as they act as an inhibitory interface between input and output nuclei. Modulation of their activity is thus thought to affect amygdala o...

the present work was performed to show the possible interaction of gab a, and gabab receptors in catalepsy. the following results were obtained: 1- muscimol (mus), a gabaa agonist, induced catalepsy. this effect was dose-dependent. baclofen (bac), a gabab agonist, had no effect in this respect. 2- catalepsy induced by muscimol was potentiated by pretreatment of animals with bicuculline (bic), a...

Objective(s) Indigofera tinctoria Linn. of Fabaceae family is claimed to be useful to control epileptic seizures in the Indian system of folkore medicine. This study was designed to evaluate I. tinctoria and to verify the claim. Materials and Methods Seizures were induced in male albino rats with pentylenetetrazole (PTZ). The test group animals were administered ethanolic extract of Indigofer...

Alpha-cypermethrin (?-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1ml) given consecutive daily orally for 60 days at 1/10LD50 (14.5mg/kg). The animals were sacrificed on day 61st. Biochemicals, cytochromeP450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum am...

In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their ?-aminobutyric acid-aminotransferase (GABA-AT) inhibition in-vivo anticonvulsant activity. Among all the synthesized derivatives, compound 7f was observed as most potent competitive inhibitor of GABA-AT (IC50 = 46.29 ± 3.19 µM, Ki 0.106 0.004 ?M). The acti...

social anxiety disorder (sad) is the one of the most common anxiety disorders. despite its high prevalence, the disorder is still considerably undiagnosed and untreated. the disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (gaba) s...

g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the synthesis of baclofen.In this study an approach has been made to...

Gamma-aminobutyric acid (GABA) has several health-promoting qualities, leading to a growing demand for natural GABA production via microbial fermentation. The GABA-producing abilities of the new Tetragenococcus halophilus (THSK) isolated from commercial soy sauce moromi were proven in this investigation. Under aerobic conditions, isolate produced 293.43 mg/L after 5 days cultivation, compared 2...