Unintended consequences of secondary prevention include potential introduction of bias into epidemiologic studies estimating genotype-disease associations. To better understand such bias, we simulated a family-based study of colorectal cancer (CRC), which can be prevented by resecting screen-detected polyps. We simulated genes related to CRC development through risk of polyps (G1), risk of CRC ...

PURPOSE Emerging evidence suggests G3 pancreatic neuroendocrine neoplasms (pNENs) present heterogeneous morphology and biology. The 2017 WHO classification has introduced a new category of well-differentiated pancreatic neuroendocrine tumors (WD-pNETs) G3, compared with poorly differentiated pancreatic neuroendocrine carcinomas (PD-pNECs) G3. We aim to analysis the demographics and outcomes of ...

Background Elderly-onset rheumatoid arthritis (EORA) has different characteristics from younger-onset RA (YORA), however, few reports have conducted large-scale and long-term comparisons of treatment disease activity between EORA YORA. Objectives To compare the changes in YORA patients to examine who achieved remission them using data a real-world database Japan. Methods Analysis was performed ...

Supplemental assays, such as recombinant immunoblot assays (RIBA), are used to confirm detection of antibodies to hepatitis C virus (HCV). However, due to their expense, they are not widely used in developing countries. The purpose of our study was to compare the results of second- and third-generation (G2 and G3, respectively) enzyme immunoassays (EIAs) and to resolve discordant results by usi...

The recognition that rotaviruses are the major cause of life-threatening diarrheal disease and significant morbidity in young children has focused efforts on disease prevention and control of these viruses. Although the correlates of protection in children remain unclear, some studies indicate that serotype-specific antibody is important. Based on this premise, current live attenuated reassorta...

Identification of the genetic architecture of phenotypic stability and management of adaptational genes is a prerequisite for improvement of adaptation. To locate the genes controlling adaptation, disomic addition lines of agropyron (agropyron elongatum, 2n=2x=14) into the genetic background of bread wheat (Triticum aestivum L., 2n=6x=42, cv. ‘Chinese Spring’=CS) were used in a randomized compl...

Background: Group A rotavirus (RVA) mainly causes acute gastroenteritis, exclusively in young children in developing countries. The prevalence and determination of the molecular epidemiology of rotavirus genotypes will determine the dominant rotavirus genotypes in the region and will provide a strategy for the development of appropriate vaccines. Methods: A total of 100 fecal samples ...

Let G3−out denote the random graph on vertex set [n] in which each vertex chooses 3 neighbors uniformly at random. Note that G3−out has minimum degree 3 and average degree 6. We prove that the probability that G3−out is Hamiltonian goes to 1 as n tends to infinity.