OBJECTIVE To assess whether improvements in cognitive and behavioral development seen in preschool educational programs persist, we compared those in a multisite randomized trial of such a program over the first 3 years of life (INT) to those with follow-up only (FUO) at 18 months of age. METHODS This was a prospective follow-up of the Infant Health and Development Program at 8 sites heteroge...

Background Fever of unknown origin (FUO) is a diagnostic challenge in children, especially differentiation of systemic onset juvenile idiopathic arthritis (SOJIA), an autoinflammatory syndrome associated with uncontrolled activation of phagocytes. In this study, we analysed the relevance of myeloid related proteins 8 and 14 (MRP8, MRP14), two endogenous activators of toll-like receptor 4, for e...

Several studies have assessed nuclear imaging tests for localizing the source of fever in patients with classic fever of unknown origin (FUO); however, the role of these tests in clinical practice remains unclear. We systematically reviewed the test performance, diagnostic yield, and management decision impact of nuclear imaging tests in patients with classic FUO. METHODS We searched PubMed, ...

There are many potential causes of FUO. Most cases are due to unusual presentations of common diseases rather than rare or exotic diseases. The key to establishing the diagnosis is a careful history and careful repeated examinations followed by targeted investigations.

Background Fever of unknown origin (FUO) and unexplained signs of inflammation are challenging medical problems and predominantly caused by infections, malignancies and noninfectious inflammatory diseases. The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDGPET) and of its combination with computer tomography technology...

OBJECTIVE To identify a set of variables that could discriminate patients with adult-onset periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome from subjects with fever of unknown origin (FUO). METHODS We enrolled 74 adults diagnosed with PFAPA syndrome according to the currently used pediatric diagnostic criteria and 62 additional patients with FUO. After ...

Disseminated tuberculosis is an important differential diagnosis for fever of unknown origin (FUO) and it can present with hepatosplenomegaly and lymphadenopathy and may have meningitis and with hematological abnormalities including pancytopenia or a leukemoid reaction. We report the case of a 13-year old male who presented with fever, weight loss, pallor and massive splenomegaly with pancytope...