Suppressor of cytokine signaling-3 (SOCS-3) is an intracellular protein that involved in a wide range of biological processes. Recently, more and more study indicated that SOCS-3 not only can down-regulate the cytokine stimulated signaling, but also can anti-inflammatory response. However, whether cytokine can induce the expression of SOCS-3 and the mechanism in airway is still unclear. Here, w...