نتایج جستجو برای: fungizone

تعداد نتایج: 133  

2007
Victoria Moneo Beatriz G. Serelde Juan F.M. Leal Carmen Blanco-Aparicio Ramon Diaz-Uriarte Miguel Aracil Juan C. Tercero José Jimeno Amancio Carnero

Aplidin (plitidepsin) is a novel anticancer drug isolated from the marine tunicate Aplidium albicans. Aplidin shows potent antitumor activity in preclinical models against a wide variety of human tumors. Aplidin is currently in phase II clinical trials in a variety of solid tumors and hematologic malignancies. Moreover, clinical studies of Aplidin in combination with other agents are ongoing be...

2011

Suppressor of cytokine signaling-3 (SOCS-3) is an intracellular protein that involved in a wide range of biological processes. Recently, more and more study indicated that SOCS-3 not only can down-regulate the cytokine stimulated signaling, but also can anti-inflammatory response. However, whether cytokine can induce the expression of SOCS-3 and the mechanism in airway is still unclear. Here, w...

2014
Andrew T. Hale Hongmei Tian Ejike Anih Fernando O. Recio Mohammad A. Shatat Trent Johnson Xudong Liao Diana L. Ramirez-Bergeron Aaron Proweller Masakazu Ishikawa Anne Hamik

Regulation of endothelial cell biology by the Notch signaling pathway (Notch) is essential to vascular development, homeostasis, and sprouting angiogenesis. While Notch determines cellfate and differentiation in a wide variety of cells, the molecular basis of upstream regulation of Notch remains poorly understood. Our group and others have implicated the Krüppel-like factor family of transcript...

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