BACKGROUND Corneal ulcer is an important cause of blindness in developing countries. Therapeutic keratoplasty for infective keratitis is a frequently performed surgery in these countries. OBJECTIVE To find out the outcome of therapeutic keratoplasty for infective keratitis. METHODS Records of 5 years were reviewed of patients who underwent therapeutic keratoplasty from 2006 to 2010. Data co...

BACKGROUND Fungal infections of self-sealing corneal incisions in cataract surgery are scarce. We report a case of Alternaria keratitis, several weeks after uneventful clear-cornea phacoemulsification. FINDINGS A 42-year-old woman, with a history of retinitis pigmentosa, complained of painful red right eye, 45 days after uneventful self-sealing clear-cornea phacoemulsification. Slit-lamp exam...

OBJECTIVE To determine the penetration of 1% voriconazole solution into the aqueous and vitreous following topical administration. METHODS A prospective nonrandomized study of 13 patients scheduled for pars plana vitrectomy surgery. Aqueous and vitreous samples were obtained and analyzed after topical administration of 1% voriconazole every 2 hours for 24 hours before surgery. Drug concentrat...

The purpose of this article is to describe the use of simultaneous noncentered photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) combined with penetrating keratoplasty in the treatment of a severe marginal Fusarium spp. keratitis case with imminent corneal perforation. It is a retrospective case report study; it was performed by collecting clinical data, images,...

Virchow first introduced the term mycosis for fungal infections. Leber (I 870) first described a case ofkeratomycosis due to Aspergillus and first established an early clinical diagnosis by mycological methods. Since his report more than thirty species of saprophytic fungi have been identified as causative agents of keratomycosis. A review of the literature for the last 20 years shows an increa...

PURPOSE Fungal keratitis (FK) is a sight-threatening disease, more prevalent in developing regions. The present retrospective study was conducted in order to evaluate the epidemiologic and clinical aspects and the progression of FK in patients treated at two ophthalmologic reference centers in Southeast Brazil. METHODS The charts of patients with infectious keratitis treated between 2000 and ...

A case of mycotic keratitis due to Curvularia senegalensis is reported. This case represents the third known reported infection caused by this rare species. Fungal hyphae were detected in corneal scrapings, and repeated cultures were positive for this fungi. The patient was presumed cured after a corneal transplant and treatment with itraconazole, but the infection recurred and the patient is w...

PURPOSE Fusarium solani and F. oxysporum were the causative organisms of the 2005/2006 outbreak of contact lens-associated fungal keratitis in the United States. The present study was an investigation of the ability of F. oxysporum grown as a biofilm on silicone hydrogel contact lenses to induce keratitis. METHODS A clinical isolate of F. oxysporum was grown as a biofilm on lotrafilcon A cont...

Background: Mycotic keratitis is a fungal infection of the cornea. This infection is difficult to treat and it can lead to severe visual impairment or blindness. It is worldwide in distribution, but is more common in the tropics and subtropical regions. Trauma is the major predisposing factor, followed by ocular and systemic defects, prior application of corticosteroids, and prolonged use of an...

Although rarely performed, corneal biopsy may be useful in establishing the diagnosis and prompt institution of appropriate management in progressive keratitis of unknown cause. Inability to obtain a definitive diagnosis in a case of chronic keratitis may be related to previous use of antimicrobials that interfere with standard cultures or by the fastidious growth of unusual pathogens in cultur...