Objective- In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.D...

BACKGROUND The purpose of this study was to evaluate the effect of use of contact lenses to improve visual outcome after repair of traumatic corneal wounds. METHODS Two groups of patients (n=30 each) with traumatic full thickness corneal wounds were entered into this study. All cases were caused by sharp objects such as a knife or piece of glass that produced a corneal full thickness wound wi...

OBJECTIVE To evaluate the effects of low-level laser therapy (LLLT) on acute, full-thickness wound healing in dogs. STUDY DESIGN Randomized block (dog); historical control. ANIMALS Adult male Beagles (n = 10). METHODS Two 2 × 2 cm(2) wounds were surgically created bilaterally on the trunk of each dog. Each side was randomized to receive LLLT (laser, LAS) or standard-of-care management (co...

A previous study by our group showed that a 44-amino-acid fragment of pigment epithelium-derived factor (PEDF) facilitated corneal epithelial wound healing. In the present study this fragment was shortened to obtain peptides of 18, 20 and 29 amino acids in length, and their promoting effects on the healing of full-thickness skin wounds were assessed. Peptides were delivered periodically by topi...

Chronic wounds, particularly diabetic ulcers, represent a main public health concern with significant costs. Ulcers often harbor an additional obstacle in the form of tunneled or undermined wounds, requiring treatments that can reach the entire wound tunnel, because bioengineered grafts are typically available only in a sheet form. While collagen is considered a suitable biodegradable scaffold ...

Thermal injuries may cause significant damage to large areas of the skin. Extensive and deep burn wounds require specialistic therapy. The optimal method in the strategy of treating extensive, full thickness burns (III°) is the use of autologous free skin grafts of intermediate thickness (1-4). The main limitation of this method is the inadequate amount of healthy, undamaged skin (donor site), ...

OBJECTIVE To evaluate the efficacy of using a porcine small intestinal submucosa (SIS) graft covered by a conjunctival flap for the surgical repair of full-thickness corneal wounds in dogs, cats and horses. PROCEDURE All records dating from August 1999 to February 2003 from Purdue University Veterinary Teaching Hospital of patients that had undergone ophthalmic surgical procedures and receive...

Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the ...

Introduction: Re-epithelialisation of cutaneous wounds is a complex multistep process. In partial thickness wounds, keratinocytes from wound edges and the remnants of the epidermal appendages contribute to the process. We investigated whether the mechanism of injury had any influence on reepithelialisation of partial thickness wounds in a porcine model. Method: Partial thickness wounds were cre...

The stimulatory effect of recombinant basic fibroblast growth factor (bFGF) on wound healing was assessed using healing-impaired (db/db) mice. Full-thickness wounds were made in female diabetic C57BL/Ksj AM mice, and their normal (db/+) littermates with a punch biopsy instrument . Recombinant bFGF was applied locally to the open wound once a day. The mice were later killed and histological sect...