The target of the present study is to use experimental design in screening and optimizing experimental variables to develop a spectrophotometric method for determination of Cefdinir (CFN) antibiotic. The proposed method is based on the oxidative coupling reaction of CFN with 3methylbenzothiazolinone-2hydrazone (MBTH) in presence of FeCl3 in acidic medium forming a green colored chromogen measur...

In this study, a new silica gel based adsorbent was fabricated and its ability in separation and quantification of alkanes mixture was investigated. Silica gel (SiO2) is a polar absorbent which is mainly used to separate polar compounds. Also, the carbon materials such as activated carbon and recently carbon nanotube (CNTs), have been widely used for separation of nonpolar materials. Carbon nan...

This study's aim is to investigate the wet and dry grindability of K-feldspar in a narrow grain size range stirred ball mill. In evaluation grinding process, full factorial design was used observe effects selected parameters on dependent variable. On grinding, parameter such as diameter, stirring speed, time, interstitial filling ratio were investigated. Experimental results showed that can be ...

When fitting complex models, such as finite element or discrete event simulations, the experiment design should exhibit good properties of both projectivity and orthogonality. To reduce experimental effort, sequential design strategies allow experimenters to collect data only until some measure of prediction precision is reached. In this article, we present a batch sequential experiment design ...

Production and purification of alpha-amylase by probiotic Lactobacillus plantarum MTCC 1407 has been investigated under submerged fermentation using Mann Rogassa Sharpe medium containing (1%) soluble starch in lieu of glucose (2%) as carbon source. Response Surface Methodology was used to evaluate the effect of main variables, i.e. incubation period, pH and temperature on enzyme production. A f...

Silicon carbide (SiC) has found a variety of engineering applications due to its superior properties. However, it is still desirable to study cost-effective processes to machine silicon carbide. This paper presents the results of a designed experimental investigation into Rotary Ultrasonic Machining (RUM) of silicon carbide. A four-variable two-level full factorial design was employed to reveal...

The purpose of this investigation was to study the effect of Bacillus subtilis CM5 in solid state fermentation using cassava bagasse for production of exo-polygalacturonase (exo-PG). Response surface methodology was used to evaluate the effect of four main variables, i.e. incubation period, initial medium pH, moisture holding capacity (MHC) and incubation temperature on enzyme production. A ful...