We have developed several monoclonal antibodies that bind specifically to IL-1 activated but not to quiescent human unbilical vein endothelial cells (HUVEC). Two antibodies, 1E7 and 2G7, were shown to react at distinct epitopes with a novel IL-1 inducible sialoglycoprotein which is implicated in the adhesion of T cells with activated endothelium (1). We used polymerase chain reaction (PCR, 2, 3...

Proper control of the cell cycle is mandatory during homeostasis and disease. The balance of p53 and MDM2 integrates numerous signalling pathways to regulate the cell cycle, which is executed by multiple proteins including the cyclins, cyclin kinases and cyclin kinase inhibitors. Mutations or environmental factors that affect cell cycle control can lead to inappropriate hyperplasia or cancer as...

We study a multi-cell multi-user MIMO full-duplex network, where each base station (BS) has multiple antennas with full-duplex capability supporting single-antenna users with either full-duplex or half-duplex radios. We characterize the upand downlink ergodic achievable rates for the case of linear precoders and receivers. The rate analysis includes practical constraints such as imperfect selfi...

At the cellular scale, blood fluidity and mass transport depend on the dynamics of red blood cells in blood flow, specifically on their deformation and orientation. These dynamics are governed by cellular rheological properties, such as internal viscosity and cytoskeleton elasticity. In diseases in which cell rheology is altered genetically or by parasitic invasion or by changes in the microenv...

The 1-bit full adder is a very important component in the design of application specific integrated circuits. Demands for the low power VLSI have been pushing the development of design methodologies aggressively to reduce the power consumption drastically. In most of the digital systems adder lies in the critical path that affects the overall speed of the system. So enhancing the performance of...

A novel low power and low transistor count static energy recovery full adder (SERF) is presented in this paper. The power consumption and general characteristics of the SERF adder are then compared against three low power full adders; the transmission function adder (TFA), the dual value logic (DVL) adder and the fourteen transistor (14T) full adder. The proposed SERF adder design was proven to...

Fetal hemoglobin (HbF) modulates the phenotype of sickle cell anemia by inhibiting deoxy sickle hemoglobin (HbS) polymerization. The blood concentration of HbF, or the number of cells with detectable HbF (F-cells), does not measure the amount of HbF/F-cell. Even patients with high HbF can have severe disease because HbF is unevenly distributed among F-cells, and some cells might have insufficie...

Due to high power consumption and difficulties with minimizing the CMOS transistor size, molecular electronics has been introduced as an emerging technology. Further, there have been noticeable advances in fabrication of molecular wires and switches and also molecular diodes can be used for designing different logic circuits. Considering this novel technology, we use molecules as the active com...

In this paper two novel high performance designs for AND and OR basic gates and a novel Full-Adder Cell are presented. These designs are based on carbon nanotube technology. In order to compare the proposed designs with previous ones both MOSFET based and CNFET based circuits are selected. By the way the proposed designs have better performance in comparison with previous designs in terms of sp...

Thy-1 is a highly abundant glycoprotein on the surface of thymocytes and neurons. A null mutation in the gene encoding Thy-1 deregulates T-cell receptor signaling and causes abnormal thymocyte development; does this mean that Thy-1 has a signaling function?