many patients with thyrotoxicosis develop hypercalciuria and nypercalcemia. urine calcium excretion depends on diet, latitude and sunshine exposure. with regard to variation of these indices in different geographical regions, we conducted a one-year study on 202 patients, 65 males and 137 females, with thyrotoxicosis of varying severity. the mean age of patients was 35.24±11.95 and 35.87±12.21 ...

Abstract Background Pulmonary vein isolation (PVI) is the cornerstone treatment for patients with atrial fibrillation (AF) refractory to medical therapy. Recent advancements have led development of contact-force (CF) sensing very-high-power short-duration (vHPSD) radiofrequency (RF) ablation (90W/4 seconds). Previous RF utilized Ablation Index (AI) as a marker lesion quality guide operator whic...

Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing plasma ammonia and glutamine in urea cycle disorders, can suppress both proinflammatory molecules and reactive oxygen species (ROS) in activated glial cells. Interestingly, NaPB also decreased the lev...

Objective: A potential risk of testosterone replacement therapy is an increase in the incidence of prostate cancer, but it is unclear whether higher levels of serum testosterone are associated with a higher risk of prostate cancer. We prospectively evaluated serum androgen concentrations and prostate cancer risk. Method: Included were 794 members of the Baltimore Longitudinal Study of Aging. We...

Rice (Oryza sativa L.) is the only cereal crop that possesses the ability to germinate under flooded or other oxygen-deficient conditions. Rapid elongation of the coleoptile is a perfect response to flooding during germination, with coleoptile length differing among various rice varieties. Despite multiple studies have uncovered valuable information concerning this trait by focusing on the phys...

A major contributing factor to the high mortality rate associated with acute myeloid leukemia and multiple myeloma is the development of resistance to chemotherapy. We have shown that the combination of tipifarnib, a nonpeptidomimetic farnesyltransferase inhibitor (FTI), with bortezomib, a proteosome inhibitor, promotes synergistic death and overcomes de novo drug resistance in acute myeloid le...

Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicardial muscle strips from 5 MR and 5 nonfailing (NF) control hearts. Myocardial ...

BMS-214662 and BMS-225975 are tetrahydrobenzodiazepine-based farnesyltransferase inhibitors (FTIs) that have nearly identical structures and very similar pharmacological profiles associated with farnesyltransferase (FT) inhibition. Despite their similar activity against FT in vitro and in cells, these compounds differ dramatically in their apoptotic potency and tumor-regressing activity in vivo...

PURPOSE To investigate whether myocardial deformation imaging, assessed by feature tracking cardiac magnetic resonance (FTI-CMR), would allow objective quantification of myocardial strain and estimation of functional recovery in patients with first time ST-elevation myocardial infarction (STEMI). METHODS Cardiac magnetic resonance (CMR) imaging was performed in 74 consecutive patients 2-4 day...

Abstract Human–computer interaction (HCI) is an for mutual communication between humans and computers. HCI needs to recognize the human state quantitatively in real-time. Although it possible evaluate condition by measuring biological signals, challenge that often requires physical constraints. There increasing interest a non-contact method of estimating physiological psychological states facia...