Normal self-renewal of follicle stem cells (FSCs) in the Drosophila ovary requires Hedgehog (Hh) signaling. Excess Hh signaling, induced by loss of patched (ptc), causes cell-autonomous duplication of FSCs. We have used a genetic screen to identify Mastermind (Mam), the Notch pathway transcriptional co-activator, as a rare dose-dependent modifier of aberrant FSC expansion induced by excess Hh. ...

A healthy diet improves adult stem cell function and delays diseases such as cancer, heart disease, and neurodegeneration. Defining molecular mechanisms by which nutrients dictate stem cell behavior is a key step toward understanding the role of diet in tissue homeostasis. In this paper, we elucidate the mechanism by which dietary cholesterol controls epithelial follicle stem cell (FSC) prolife...

In view of the presence of some 190 mutations in the low density lipoprotein receptor (LDL-R) gene and a lack of simple detection methods, we have developed an improved assay system for detecting familial hypercholesterolemia (FH) using mitogen-induced proliferating lymphocytes. Freshly isolated mononuclear cells were cultured for 3 days in RPMI 1640 supplemented with 10% human lipoprotein-defi...

Extragalactic sources from the IRAS Faint Source Catalog (FSC) which have the optically faintest magnitudes (E & 18) were selected by spatial coincidence with a source in the FIRST radio survey, and 28 of these sources have been observed with the Infrared Spectrograph on Spitzer (IRS). While an infrared source is always detected with the IRS at the FIRST position, only ∼ 50% of the infrared sou...

The quantification of food losses and waste (FLW) has become a research hotspot in the last decade, but little work been done to have data Latin American countries. This paper contributes addressing this knowledge gap by examining magnitude FLW along whole supply chain (FSC) Peru. methodological approach was based on top-down mass flow analysis at all steps FSC for 2007–2017 period (most recent...

Stem cells are critical for maintaining tissue homeostasis and are commonly governed by their niche microenvironment, although the intrinsic mechanisms controlling their multipotency are poorly understood. Polycomb group (PcG) genes are epigenetic silencers, and have emerged recently as important players in maintaining stem cell multipotency by preventing the initiation of differentiation progr...

Among the reported single gene disorders/syndrome, hemoglobin infection is the most common and widespread genetic disorder. Thalassemia arises from defect in red blood cell proteinaceous component (hemoglobin), which carries oxygen and may lead to anemia. Present study aimed to detect the common molecular abnormalities of β-thalassemia syndrome in district Nowshehra, Khyber Pakhtunkhwa, Pakista...

The number of real-time applications, such as video-on-demand and video conferencing, is rapidly increasing. Realtime data now occupies a significant portion of network traffic. These applications require real-time service; as such, they need to bound end-to-end delays. Generally, real-time service is provided by reserving bandwidth in advance. Thus, to admit a large number of real-time applica...

Inflammation plays a pivotal role in the development and progression of cardiovascular diseases, in which, the endothelium dysfunction has been a key element. The current study was designed to explore the vasodilatory effect of anti-inflammatory herbs which have been traditionally used in different clinical applications. The total saponins from Actinidia arguta radix (SAA), total flavonoids fro...

The digitalization of production engineering, known as “Industry 4.0”, has a direct impact on the Supply Chain. When financial assets are the resources of this value chain, this is called together with its processes and products Financial Supply Chain (FSC). Thus the question arises whether progress by Industry 4.0 does have any impact on central services of the FSC and therefore on the banking...