A simple, rapid and sensitive liquid chromatography-mass spectrometry (LC-MS) method was developed for the determination of salidroside in rat plasma and study of its pharmacokinetics after oral administration of suspension of Erzhi Wan and Fructus Ligustri lucidi into Wistar rats. Plasma sample of 200 μL was extracted with acetic ether-isopropanol (2:1) and the extraction was performed on a Kr...

Organic acids in Chinese herbs, the long-neglected components, have been reported to possess antioxidant, anti-inflammatory, and antiplatelet aggregation activities; thus they may have potentially protective effect on ischemic heart disease. Therefore, this study aims to investigate the protective effects of two organic acids, that is, citric acid and L-malic acid, which are the main components...

Achieving long-term allograft survival without continuous global immunosuppression is highly desirable because constant immunosuppression causes severe side effects. Traditional Chinese medicine (TCM) has been utilized to treat numerous diseases for centuries. To seek novel immunosuppressive agents, we investigated several Chinese herbal formulas that have been shown to be effective in treating...

The optimal conditions for preparation of total phenolic acids in Phyllanthus emblica, and to study their inhibitory effect on human hepatoma cells have been investigated. The conditions for extraction of phenolic acid constituents in Phyllanthus emblica were investigated, and single factor and orthogonal tests were performed on conditions such as extraction solvent, extraction temperature, ext...

This study was designed to confirm the protective effect of Schisandrae Fructus, which are the dried fruits of Schisandra chinensis (Turcz.) Baill, against oxidative stress-induced cellular damage and to elucidate the underlying mechanisms in C2C12 myoblasts. Preincubating C2C12 cells with a Schisandrae Fructus ethanol extract (SFEE) significantly attenuated hydrogen peroxide (H2O2)-induced inh...

BACKGROUND The current astringency evaluation for herbs has become dissatisfied with the requirement of pharmaceutical process. It needed a new method to accurately assess astringency. METHODS First, quinine, sucrose, citric acid, sodium chloride, monosodium glutamate, and tannic acid (TA) were analyzed by electronic tongue (e-tongue) to determine the approximate region of astringency in part...

A join-completion of a poset is a completion for which each element is obtainable as a supremum, or join, of elements from the original poset. It is well known that the join-completions of a poset are in one-to-one correspondence with the closure systems on the lattice of up-sets of the poset. A ∆1-completion of a poset is a completion for which, simultaneously, each element is obtainable as a ...

A flow-injection mass spectrometric (FIMS) fingerprinting method in combination with principal component analysis (PCA) was used to study the geo-herbalism of Evodiae Fructus (EF) samples. Twenty four EF samples from different regions in China were collected and analyzed. The PCA scores plot showed that the samples from Guizhou Province were scattered in different groups, however, most of the s...