Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate was synthesized using Friedel–Crafts acylation between N-methyl indole and methyl 9-chloro-9-oxononanoate. The structure of the newly compound elucidated 1H-NMR, 13C-NMR, NOESY-1D, ESI-MS, FT-IR, UV-Vis spectroscopy.

A highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides catalyzed by chiral PYBOX-DIPH-Zn(II) complexes has been developed. The catalyst offers substantial substrate scope and furnished alkylated pyrroles in excellent yields (up to 99%) and enantioselectivities (up to >99% ee).

The first highly efficient double Friedel-Crafts reaction of N-tosyl imines with anisole, phenol, thioanisole and analogues has been developed to produce the corresponding symmetric diarylmethanes and triarylmethanes with high regioselectivity in the presence of a catalytic amount of Bi(2)(SO(4))(3)-TMSCl at room temperature.

We introduce a path-integral approach that allows to compute charge density oscillations in a Luttinger liquid with impurities. We obtain an explicit expression for the envelope of Friedel oscillations in the presence of arbitrary electron-electron potentials. As examples, in order to illustrate the procedure, we show how to use our formula for contact and Coulomb potentials. Pacs: 05.30.Fk, 71...

Novel and efficient Brønsted acid (p-TsOH) catalyzed inter- and intramolecular Friedel-Crafts alkylations have been developed to synthesize selenated three-component coupling and selenation-cyclization indole derivatives. Chemical removal of the phenylseleno moiety was investigated, and the reaction mechanisms were discussed.

MAIK FRIEDEL†, SWETLANA NIKOLAJEWA‡ and THOMAS WILHELM§ †Biocomputing Group, Fritz Lipmann Institute (FLI), Beutenbergstr. 11, D-07745 Jena, Germany Email: [email protected] ‡Department of Bioinformatics, Friedrich Schiller University Jena, Ernst-Abbe-Platz 2, D-07743 Jena, Germany §Theoretical Systems Biology, Institute of Food Research, Norwich Research Park, Norwich NR4 7UH, United Kingd...

1-Indanones have been successfully prepared by means of three different non-conventional techniques, namely microwaves, high-intensity ultrasound and a Q-tube™ reactor. A library of differently substituted 1-indanones has been prepared via one-pot intramolecular Friedel-Crafts acylation and their efficiency and "greenness" have been compared.

An inter- as well as intra-molecular thia-Pictet-Spengler cyclization of N-tethered thiols and vinylogous thiocarbonates is described for the stereoselective synthesis of N-fused thiazinoindole derivatives. The strategy is extended to one-pot, sequential Friedel-Crafts alkylation - Pictet-Spengler cyclization and the synthesis of thiazino-oxepino-indole.