In modern clinical practice, combination fixed - dose tablets have become a baseline foreffective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In thisstudy, the tablets were prepared by wet granulation method and characterized in terms of weightvariation, hardness, friability, d...

   Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...

   Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...

INTRODUCTION Pulsatile Drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Pulsatile Drug Delivery systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of envir...

BACKGROUND As the most common form of dementia, Alzheimer disease is characterized by progressive loss of memory and deterioration of cognitive functions. It is predicted that about 75.63 million people would suffer from dementia by 2030. Apart from conventional remedies, the application of herbal medicines is on the rise. There are numerous natural medicaments reported in the traditional manus...

INTRODUCTION Misoprostol (Cytotec) is recognised to be effective for many gynaecological indications including termination of pregnancy, management of miscarriage and postpartum haemorrhage. Although not licensed for such indications, it has been used for these purposes by millions of women throughout the world. Misoprostol tablets are most often packaged as multiple tablets within an aluminium...

In the present work, fast dissolving tablets of granisetron HCl were prepared using low compressible (mannitol) and high compressible saccharides (sorbitol 5-15% w/w) along with crospovidone, croscarmellose sodium and L-HPC as super-disintegrants in different ratios(2-8% w/w) In case of sorbitol, the presence of interlocking crystals that are generated using specific manufacturing conditions en...

the objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

background: orally disintegrating tablets (odts) are a modern form of tablets that when placed in the oral cavity, disperses rapidly. these tablets have advantages, particularly good applications for children and old patients who have a complication in chewing or swallowing solid dosage forms. the aim of this study was to design, formulate, and evaluate the physicochemical properties of 5 mg mo...

Solid dosage forms are invariably multiparticulate systems of heterogenous particle size distribution. The purpose of this study was to investigate the effect of particle size distribution of paracetamol granules on some tablet mechanical properties of paracetamol tablets. Granules were formed by wet massing paracetamol powder (200 g) with 20% (w/w) of maize starch mucilage as binder. Resulting...