Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfram Syndrome 2) and in BCL-2 mediated antagonization of Beclin 1-dependent autophagy and depression of ER calcium stores. To gain insights about NAF...

The Evans blue dye (EBD; 961 Da) and the sodium fluorescein dye (NaF; 376 Da) are commonly used inert tracers in blood-brain barrier (BBB) research. They are both highly charged low molecular weight (LMW) tracers with similar lipophobic profiles. Nevertheless, the EBD binds to serum albumin (69,000 Da) to become a high molecular weight (HMW) protein tracer when injected into the circulation, wh...

Synthesis of lanthanide-doped upconversion nanocrystals (LDUNs) with controlled morphology and luminescence has long been desired in order to fulfill various application requirements. In this work, we have investigated the effect of the NaF : Ln(3+) molar ratio, in the range of 1 to 20, on the morphology, crystal structure, and upconversion properties of NaxScF(3+x):Yb/Er nanocrystals that are ...

Dun, Wen, Parag Chandra, Peter Danilo, Jr., Michael R. Rosen, and Penelope A. Boyden. Chronic atrial fibrillation does not further decrease outward currents. It increases them. Am J Physiol Heart Circ Physiol 285: H1378–H1384, 2003; 10.1152/ajpheart.00137.2003.—Rapid atrial pacing causes electrical remodeling that leads to atrial fibrillation (AF). AF can further remodel atrial electrophysiolog...

Abstract Background Fluoride may induce oxidative stress and apoptosis. It also lead to neurobehavioural defects including neuromuscular damage. The present study aimed explore the effects of sub lethal concentrations sodium fluoride (NaF) on lifespan climbing ability Drosophila melanogaster. In total, 0.6 mg/L 0.8 NaF were selected as sublethal for study. Lifespan was measured activity assay p...

BACKGROUND Sodium fluoride is the preferred agent to inhibit glycolysis. Its action is not immediate, however, and complete inhibition is delayed for up to 4 hours. A more effective method is needed. Acidification of blood combined with the addition of NaF and EDTA appears to be such a method. We studied whether acidification was indeed more effective than NaF. METHODS We conducted 6 independ...

Gallic acid has been identified as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fluoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m(-3) for one week). Gallic acid at 10 mg kg(-1) and 20 mg k...

Regulation of cell volume is an important aspect of cellular homeostasis during neural activity. This volume regulation is thought to be mediated by activation of specific transporters, aquaporin, and volume regulated anion channels (VRAC). In cultured astrocytes, it was reported that swelling-induced mitogen-activated protein (MAP) kinase activation is required to open VRAC, which are thought ...