resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we als...

Free energy perturbation methods using molecular dynamics have been used to calculate the absolute free energy of association of two ligand-protein complexes. The calculations reproduce the significantly more negative free energy of association of biotin to streptavidin, compared to N-L-acetyltryptophanamide/alpha-chymotrypsin. This difference in free energy of association is due to van der Waa...