Abstract Inhibitory receptors called “immune checkpoints” restrict overzealous immune responses during inflammatory events such as infection or cancer. Blocking the function of these checkpoints using monoclonal antibodies can tip balance towards activation and disease clearance, which has been a revelation in treatment various cancers. Considering recent advances have shown that dysregulation ...

The Cognitive Map Probe (CMP) is a novel Virtual Reality interface that attempts to assess the cognitive mapping abilities of its users. The CMP uses a tangible user interface (TUI) in order to support natural acquisition and straightforward assessment of cognitive maps. It is directed at the assessment of early Alzheimer Disease (AD) by measuring the decline in cognitive mapping abilities, a d...

The newly defined Frazer Beach Member of the Moon Island Formation is identified widely across Sydney Basin in both outcrop and exploration wells. This thin unit was deposited immediately after extinction Glossopteris flora (defining terrestrial end-Permian event). rests conformably on uppermost Permian coal seam most places. A distinctive granule-microbreccia bed locally represented at base me...

objective: the two most frequent hypochromic microcytic anemias are β- thalassemia minor (btm) and iron deficiency anemia (ida). several discrimination indices have been proposed to quickly discriminate these similar entities via parameters obtained from automated blood count analyzers. the aim of this study to evaluate the diagnostic reliability of ten discrimination indices in the differentia...

The response of vertical arrays at single frequencies (CW) and for homogeneous media is well known. This paper addresses the issues of frequency dependence and sound velocity gradients for the vertical array response in a deep ocean. I have modified the synthetic seismogram code of Neil Frazer, Subhashis Mallick and Dennis Lindwall to address this problem. The code uses a rearrangement of the K...

ACADEMIC STRESS, TEST ANXIETY, AND PERFORMANCE IN A CHINESE HIGH SCHOOL SAMPLE: THE MODERATING EFFECTS OF COPING STRATEGIES AND PERCEIVED SOCIAL SUPPORT by Juan “Tulip” Xiao Test taking can produce elevated stress and anxiety, with subsequent negative influences on test performance. This has been a focus of prior research. However, only a few studies have explored how coping strategies and perc...

Coronary artery disease (CAD) is one of the most common cardiovascular diseases and has a high incidence of morbidity and mortality. CAD is a major public health problem in developing and developed countries and its increasing prevalence is a cause of considerable concern in the medical community worldwide (He et al., 2005). CAD involves genetic and environmental factors and their interaction w...