نتایج جستجو برای: fracture healing
تعداد نتایج: 154552 فیلتر نتایج به سال:
Fracture healing, in which osteoclasts and osteoblasts play important roles, has drawn much clinical attention. Osteoclast deficiency or decreased osteoblast activity will impair fracture healing. TRPV1 is a member of the Ca2+ permeable cation channel subfamily, and pharmacological inhibition of TRPV1 prevents ovariectomy-induced bone loss, which makes TRPV1 a potential target for osteoporosis....
Management of osteoporotic fracture is challenging. In most clinical settings, skeletal regenerations are biologically optimized, but still many patients continue to experience delayed or impaired healing. Methods to enhance these healing processes, are needed to decrease patient’s agony, so that they can return to their work and regain their socioeconomic status in the community. Till this tim...
Therapeutic enhancement of fracture healing would help to prevent the occurrence of orthopedic complications such as nonunion and revision surgery. Sclerostin is a negative regulator of bone formation, and treatment with a sclerostin monoclonal antibody (Scl-Ab) results in increased bone formation and bone mass in animal models. Our objective was to investigate the effects of systemic administr...
BACKGROUND AND PURPOSE It is not known whether there is a difference in bone healing after external fixation and after intramedullary nailing. We therefore compared fracture healing in rats after these two procedures. METHODS 40 male rats were subjected to a standardized tibial shaft osteotomy and were randomly assigned to 2 treatment groups: external fixation or intramedullary nailing. Evalu...
Introduction: Horizontal root fracture (HRF) generally has a good prognosis of healing at fracture line after repositioning and flexible splinting. However, various factors such as delayed referral may unfavorably influence close reduction of firmly displaced coronal fragments and the long-term prognosis of healing at fracture line. Case 1: A 25-year-old woman with HRF in her maxillary central ...
Microarray analysis of gene expression was performed in the healing femur fractures of 13-week-old male rats during the inflammatory stageof repair, at 3 days post-fracture, and the endochondral bone formation stage of repair, at 11 days post-fracture. Multiple replicate pairs of fracturetissues paired with unfractured tissues, and unfractured control bones that had the stabilizing K-wi...
BACKGROUND The aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model. MATERIALS AND METHODS Eighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated wi...
The stiffness of fracture fixation devices together with musculoskeletal loading defines the mechanical environment within a long bone fracture, and can be quantified by the interfragmentary movement. In vivo results suggested that this can have acceleratory or inhibitory influences, depending on direction and magnitude of motion, indicating that some complications in fracture treatment could b...
Over one million fractures occur per year in the US and are associated with impaired healing increasing patient morbidity, stress, and economic costs. Despite improvements in surgical technique, internal fixation, and understanding of biologics, fracture healing is delayed or impaired in up to 4% of all fractures. Complications due to impaired fracture healing present therapeutic challenges to ...
PURPOSE: The hypoxia-signaling pathway regulates endochondral ossification, and is critically important for proper modulation of inflammation, angiogenesis, and osteogenesis following trauma. Although hypoxia inducible factor-1α (Hif-1α) and hypoxia inducible factor-2α (Hif2α) are critical mediators of this pathway, the role of these factors in fracture healing remains unclear, particularly wit...
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