OBJECTIVE Systemic sclerosis-associated pulmonary arterial hypertension differs from idiopathic pulmonary arterial hypertension with respect to histopathology, treatment responses and survival. Medical progress on PAH is hampered by the lack of human biosamples and suitable animal models. In this study, the authors evaluated fos-related antigen 2 (Fra-2) transgenic mice as a novel model for sys...

Among the several effectors that mediate TNF-alpha action is AP-1, which consists of transcription factors belonging to the JUN and FOS families. Although the effects of TNF-alpha in immune cells, such as the induction of NF-kappaBeta, are well known, the mechanisms by which it induces transcriptional activation of AP-1 in pulmonary epithelial cells are not well defined. In this study, we repor...

power transformers are key components in electrical power supplies and their failure could cause severe consequences on continuity of service and also generates substantial costs. identifying problems at an early stage, before catastrophic failure occurs, is a great benefit for reliable operation of power transformers. frequency response analysis (fra) is a new, well-known and powerful diagnost...

BACKGROUND Evaluate and compare the utility of serum folate receptor alpha (FRA) and megakaryocyte potentiating factor (MPF) determinations relative to serum CA125, mesothelin (MSLN) and HE4 for the diagnosis of epithelial ovarian cancer (EOC). METHODS Electrochemiluminescent assays were developed for FRA, MSLN and MPF and used to assess the levels of these biomarkers in 258 serum samples fro...

A longitudinal study of IQ and cognitive profile in 18 fra(X) positive boys is reported. At the time of diagnosis, four of the boys were mildly retarded, seven were moderately retarded, and five were severely mentally retarded. Intelligence was borderline in one child and normal in another. A decline in intellectual performance with age in the fra(X) syndrome indicated in previous studies was n...

Frequency response analysis (FRA) is a powerful and widely used tool for condition assessment in power transformers. However, interpretation schemes are still challenging. Studies show that FRA data can be influenced by parameters other than winding deformation, including temperature. In this study, machine-learning approach with temperature as an input attribute was to objectively identify fau...

The U.S. Nuclear Regulatory Commission (NRC) fire risk research program has several tasks aimed at improving the nuclear power plant fire risk assessment (FRA) state of the art. Current results to date include an evaluation of available test data relevant to the estimation of fire-induced spurious actuation probabilities, FRA methodology issues raised by a review of past fire events, and a fram...

F6A, a molecular clone of subgroup A feline leukemia virus (FeLV) is considered to be highly infectious but weakly pathogenic. In recent studies with a closely related subgroup A molecular clone, FRA, we demonstrated high pathogenicity and a strong propensity to undergo recombination with endogenous FeLV (enFeLV), leading to a high frequency of transition from subgroup A to A/B. The present stu...