the main objective of present research work is to formulate the clopidogrel fast dissolving tablets. clopidogrel, an antiplatelet drug, belongs to bcs class-ii and used to control heart attack, hypertension by inhibiting platelet activation and aggregation .the fast dissolving tablets of clopidogrel were prepared employing different concentrations of crospovidone and croscarmellose sodium in di...

In this paper a non-diagonal regulator, based on the QFT method, is synthesized for an uncertain MIMO plant whose output and control signals are subjected to hard time-domain constraints. This procedure includes the design of a non-diagonal pre-controller based on a new simple approach, followed by the sequential design of a diagonal QFT controller. We present a new formulation for the latter s...

Background: Thermal stability (TS) is a part of the BCG vaccine characterization by which the consistency of process in BCG vaccine production could be confirmed. To enhance the TS of the vaccine, some prevalent stabilizers in different concentrations were added to the final formulation of BCG bulk prior to Freeze-drying process. We found a formulation more effective than the current stabilizer...

the objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

This paper introduces a new formulation for analysis and design of modulated lter banks. A unique feature of the formulation is that it provides explicit control of the input-to-output system delay. The paper discusses minimum delay lter banks and demonstrates that truly exact reconstruction is possible in this context. The formulation provides a broad range of design exibility within a compact...

this study is devoted to the formulation of the network design problem of one-way streets and the application of simulated annealing (sa) algorithm to solve this problem for a large real network. it discusses some points of views on one-way street networks, the objective function used for design, the way in which design constraints may be considered, and the traffic problems concerning one-way ...

Automatic design optimization is highly sensitive to problem formulation. The choice of objective function, constraints and design parameters can dramatically impact the computational cost of optimization and the quality of the resulting design. The best formulation varies from one application to another. A design engineer will usually not know the best formulation in advance. In order to addre...

Silver ion has been used for centuries to prevent and treat a variety of diseases and infections. In recent years, extensive studies have been undertaken on the use of antimicrobial properties of silver, incorporated within medical devices. The aim of this study was to prepare a formulation containing silver ion, which could be applied for wound dressing. The purity of nanosilver was measured b...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...