As part of a PhD on code forking in open source software, Linus Nyman looked into the origins of how the practice came to be called forking. This search led to the early history of the fork system call. Having not previously seen such a history published, here we look back at the birth of the fork system call to share what was learned, as remembered by its pioneers. The fork call allows a proce...

DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork and reassembly behind. An unresolved issue concerns how histone dynamics are coordinated with fork progression to maintain chromosomal stability. Here, we characterize a complex in which the human histone chaperone Asf1 and MCM2-7, the putative replicative helicase, are connected through a histone H3-H4 b...

Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to DNA double-strand breaks (DSBs) that will be preferentially repaired by homologous recombination when the sister chromatid is available. The Rrm3 helicase is a replisome component that promotes replication upon fork stalling, accumulates at highly transcribed regions and preve...

Fork-based symbolic execution would waste large amounts of computing time and resource on invulnerable paths when applied to vulnerability detection. In this paper, we propose a statically-guided fork-based symbolic execution technique for vulnerability detection to mitigate this problem. In static analysis, we collect all valid jumps along vulnerable paths, and define the priority for each pro...

The advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique opportunity to regulate fork advance and stability. Through post-translational histone modifications...

The Fork Calculus FC presents a theory of communicating systems in family with CCS, but it differs in the way that processes are put in parallel. In CCS there is a binary parallel operator |, and two processes p and q are put in parallel by p|q. In FC there is a unary fork operator, and a process p is activated to “run in parallel with the rest of the program” by fork(p). An operational semanti...

PriA, a 3' --> 5' DNA helicase, directs assembly of a primosome on some bacteriophage and plasmid DNAs. Primosomes are multienzyme replication machines that contribute both the DNA-unwinding and Okazaki fragment-priming functions at the replication fork. The role of PriA in chromosomal replication is unclear. The phenotypes of priA null mutations suggest that the protein participates in replica...