Over-production of hydrogen peroxide (H2O2) will lead to human osteoblast dysfunction and apoptosis, causing progression of osteoporosis and osteonecrosis. NF-E2-related factor 2 (Nrf2) is a well-characterized anti-oxidant signaling. Cullin 3 (Cul3) ubiquitin E3 ligase dictates Nrf2 degradation. We demonstrate that microRNA-455 ("miR-455") is a putative Cul3-targeting microRNA. Forced-expressio...

Metabolomics aims at gathering the maximum amount of metabolic information for a total interpretation of biological systems. A process analytical technology pipeline, combining gas chromatography-mass spectrometry data preprocessing with multivariate analysis, was applied to a Port wine "forced ageing" process under different oxygen saturation regimes at 60°C. It was found that extreme "forced ...

Large-scale dairy farms around Damascus do not have enough land for forage cultivation mainly due to high price of land, allocation of land for vegetable production, which is more economically important than fodder cultivation and unfavourable climatic factors. Farms are therefore forced to transport roughage from distant crop cultivating areas. In the case of the dairy farm described in this w...

Oxygen glucose deprivation (OGD) application in cultured human umbilical vein endothelial cells (HUVECs) mimics ischemic injuries. AntagomiR-451, the miroRNA-451 ("miR-451") inhibitor, could activate pro-survival AMP-activated protein kinase (AMPK) signaling. In the current study, we showed that forced-expression of antagomiR-451 depleted miRNA-451 and significantly attenuated OGD-induced necro...

AIMS To investigate a worker who experienced systemic and respiratory symptoms when exposed to a vanadium containing powder used as a catalyst in the production of maleic anhydride. METHODS The investigation included inhalation challenge with the suspected compound combined with monitoring of lung function tests and post-challenge bronchoalveolar lavage. RESULTS Exposure to the vanadium con...

This paper presents a decision making approach for mid-term scheduling of large industrial consumers based on the recently introduced class of Stochastic Dominance (SD)constrained stochastic programming. In this study, the electricity price in the pool as well as the rate of availability (unavailability) of the generating unit (forced outage rate) is considered as uncertain parameters. The self...

Introduction Based on a parliamentary decision, in the year 2009 castration of male piglets without anesthesia will be banned in Switzerland. Thus, pig producers are forced to search for alternatives to the common practice. Rearing intact male pigs to market weight could constitute one possible alternative solution. However, producers, retailers, and consumers are concerned about the incidence ...

Rhodes RE, Zehr EP. Br J Sports Med Month 2017 Vol 0 No 0 Spoiler alert! This paper deals with plot points found in the GRR Martin books in the ‘Song of Ice and Fire’ series and the ‘Game of Thrones’ television production seasons 1–6. If you haven’t yet caught up (and why haven’t you?), please proceed at your own risk. You have been warned! Fight, flight or finished: forced fitness behaviours i...

I formulate a quantum stochastic thermodynamics for the quantum trajectories of a continuously monitored forced harmonic oscillator coupled to a thermal reservoir. Consistent trajectory-dependent definitions are introduced for work, heat, and entropy, through engineering the thermal reservoir from a sequence of two-level systems. Within this formalism the connection between irreversibility and ...

Enterprises in all branches of industry are being forced to react to the growing individualization of demand, yet, at the same time, increasing competitive pressure dictates that costs must also continue to decrease. Companies have to adopt strategies which embrace both a closer reaction to the customers’ needs and efficiency. Mass Customization meets this challenge by offering individually cus...