This review covers new mechanistic information spanning the past 10 years relevant to normal and abnormal thyroid growth and function that may assist in the risk assessment of chemicals inducing thyroid follicular cell neoplasia. Recent studies have shown that thyroid regulation occurs via a complex interactive network mediated through several different messenger systems. Increased thyroid-stim...

INTRODUCTION Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature...

For several decades, researchers worldwide report a decrease in fertility in high-yielding dairy cows, most probably based on conflicting metabolic and reproductive needs. The dairy herd manager's success at improving milk production has been accompanied by a negative trend for the most visible reproductive parameters such as calving intervals, number of days open and number of inseminations ne...

Follicular formation, growth or atresia, and ovulation as well as luteal formation and subsequent regression are dependent upon cyclical remodeling of the extracellular matrix (ECM). The proteinaceous and nonproteinaceous components of the ECM provide the tissue specific, extracellular architecture to which cells attach. Furthermore, the ECM modulates cellular activities through cellular surfac...

cAMP mediates the effects of TSH by regulating thyroid follicular cell proliferation, differentiation, and function. To assess the functional importance of the cAMP response element binding protein (CREB) in thyroid follicular cell regulation in vivo, we targeted the expression of a dominant negative (DN) CREB isoform to the thyroid glands of transgenic mice using a tissue-specific promoter. Tr...

ACTIVITY of the hair follicle is cyclic, periods of hair-growth alternating with periods of quiescence during which the dead hair is retained as a 'club'. In the rat, hair-growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958a). The object of our work was to find out how far such activity is dependent upon factors ...

introduction: adult stem cells are the group of cells which conserve their nature in tissues and organs among other cells. in recent years, the researchers reported the existence of stem cells on the bulge of hair follicles near to the smooth muscle. it is possible to differentiate these stem cells to neural cells by induction of shh, fgf, and ra factors. because of existence of these factors i...

The emergent concepts on ovary environment, reproductive physiology and the development of pharmacology are constantly supporting the advance of assisted reproduction. Within the last years, the biotechnics related to the synchronization of follicular development and the manipulation of bovine estrus cycle have progressed rapidly and consistently. The combined use of timed-artificial inseminati...

The objective of this study was to compare the effectiveness of the protocols for superstimulation of follicular growth in Thai native heifers. Heifers (n = 20) were randomly divided into four groups of five heifers/group. Heifers were given a single dose by i.m. administration of 100 mg Follicle Stimulating Hormone dissolved in polyvinylpyrrolidone (FSHp) at 24 h. Ovum pick up (OPU) occurred a...

The overall aim of the present thesis was to progress in the understanding of the pathogenic and diagnostic meaning of some numerical and structural chromosomal abnormalities that are frequently detected in follicular cell derived tumors of the thyroid. The flow cytometry study of 143 thyroid lesions revealed that the aneuploidy in follicular tumors is strongly associated with a particular morp...