نتایج جستجو برای: fok1 polymorphism
تعداد نتایج: 107356 فیلتر نتایج به سال:
glaucoma is a major cause of blindness worldwide. a single nucleotide polymorphism of the mthfr gene (c677t) has been associated with susceptibility to this disease, although this is controversial in the last decade. in this study, the possible association between the mthfr c677t polymorphism and the risk of developing primary open angle (poag) and pseudoexfoliation glaucoma (pexg) was investig...
Background: Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients. Methods:In this case-control study, 90 patients with thyroid tumors ...
Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were descri...
Background and purpose: The human multidrug resistance gene (MDR1) encodes for P-glycoprotein (P-gp) which is a transmembrane transporter protein acts as an efflux pump for a number of xenobiotics. It plays a protective role for cells against DNA damage caused by toxins and drugs. The wobble C3435T polymorphism at exon 26 has been associated with different expression levels and activities of th...
Objective(s): The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Resul...
Background: The scavenger receptor class B type I (SR-BI), as the high density lipoprotein cholesterol (HDL-C) receptor, is a key component in the reverse cholesterol transportation. The objective of this study was to assess the association between exon1 (G→A) polymorphism of SR-BI gene and lipid profiles among the Tehran Lipid and Glucose Study (TLGS) population. Methods: This cross-se...
Introduction & Objective: Adiponectin exerts anti-tumor effect through connection to its receptor. Some studies have shown that polymorphism in Adipor1 results in insulin resistance, diabetic type 2 and colorectal cancer (CRC). The purpose of this study is to investigate the incidence mutant allele of adiponectin receptor 1 polymorphism rs2275738 and to examine the association of genetic vari...
Background: Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results. Objective: This study aims to investigate the possible association between rs3918242 (−1562C>T) polymorphism in Matrix Metalloproteinase 9 (M...
Background and purpose: Gastric cancer is one of the most prevalent cancers with a low-five year survival rate. Some factors such as molecular pathway are associated with the development of disease and metastasis is the most important factor for death. Caspase 9 is initiator CASP of internal apoptosis pathway and have important role in cancer development. Polymorphism of CASP 9 gene promoter co...
Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...
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