OBJECTIVE Foetal ductal problems may have various cardiopulmonary consequences. This study aimed to identify the spectrum of ductus arteriosus (DA) dysfunction (closure, constriction, kinking, aneurysm and thrombosis) and the resultant clinical and echocardiographic presentation in foetuses and neonates. METHODS AND RESULTS This is a retrospective analysis of serial pre- and post-natal data o...

Foetal ovarian cysts are the most frequently encountered intra-abdominal cystic masses diagnosed prenatally. The aetiology of foetal ovarian cysts is still unknown, but hormonal stimulation is generally considered to be responsible for the disease. The diagnosis is made by the exclusion of other cystic lesions confined to the foetal abdomen. In this article we report antenatally-detected foetal...

The data presented clearly suggest that relative amounts of mRNAs for elastins a, b and c are developmentally regulated in foetal-calf nuchal ligament and aorta and that this regulation is tissue-specific. In nuchal ligament, at earlier stages of foetal development, the relative amounts of mRNAs for elastins a and b are very low. After the foetal age of about 6 months the relative amount ofmRNA...

1. Premature delivery of foetal rats by uterine section results in the rapid appearance of tyrosine aminotransferase activity in foetal liver, after an initial lag period of 3-6hr. 2. The premature induction of activity is completely repressible by actinomycin D given soon after delivery and partially repressible by puromycin and amino acid analogues. 3. Glucagon injections into foetal rats in ...

The weight difference between large, small and unselected strains of mice were maintained when blastocysts of each genotype were transferred to unselected control recipients, suggesting that foetal genotype was an important factor in determining prenatal body size. The asynchronous transfer of large, small and unselected embryos resulted in a highly significant (P less than 0-001) elevation of ...

Iron incorporation (59Fe) into erythropoietic cells from adult and foetal (11- to 15-day) peripheral blood and from foetal (12- to 15-day) livers has been investigated. Ion-exchange chromatography of haemolysates from such cells revealed two groups of 59Fe-containing proteins. The first group (X-fraction) was eluted from CMC-columns in the void volume and was highest in lysates of immature eryt...

BACKGROUND & OBJECTIVES Doppler velocimetry studies of placental and foetal circulation can provide important information regarding foetal well-being providing an opportunity to improve foetal outcome. The present study was undertaken to evaluate the role of middle cerebral to umbilical artery blood velocity waveform's systolic/diastolic ratio (MCA/UA) and biophysical profile as a predictor of ...

Pathology is the field in medicine dealing with structural and functional changes in tissues and organs which cause or are caused by disease (Taylor, 1988). Foetal pathology is encountered in the foetus aborted either deliberately or spontaneously during the first trimesters of pregnancy (Keeling, 1994). Foetal pathology differs from general pathology in many ways; by focussing on the developme...

1. Although disrupted parturition and high foetal losses have previously been reported in pregnant rats maintained on zinc-deficient diets this is the first report to differentiate between the effects of reduced Zn intake and the effects of reduced food intake on the outcome of pregnancy in the rat. 2. Rats maintained on a 0.5 mg Zn/kg diet for the last 7 d of gestation or on a 5 mg Zn/kg diet ...