An antibody raised against keratan sulphate was used to localize keratan sulphate in the human embryonic cornea and other human foetal organs. It was found that keratan sulphate was present in the corneal endothelium, as well as in the corneal stroma. In contrast, no keratan sulphate could be demonstrated in the corneal epithelium or in any posterior parts of the human foetal eye. Human corneal...

1. Chronically cannulated sheep foetuses and suckling lambs were injected with 14C-labelled glucose, fructose or lactate, and sequential blood samples taken under conditions of minimal stress and without anaesthesia. 2. Gluconeogenesis from lactate was not detectable in foetal sheep, but the pathway was active in suckling lambs. 3. Fructose utilization rates were low in foetal sheep, with no me...

Hepatocyte transplantation has become an alternative to orthotopic liver transplantation for the treatment of liver metabolic diseases. However, there is an increasing lack of donor organs and isolated mature hepatocytes are difficult to manipulate and cannot be expanded in vitro. It is therefore necessary to find alternative sources of hepatocytes, and different approaches to evaluate the ther...

Objective: To study maternal and foetal outcome of pregnancy in women with heart disease with history of corrective surgery/ intervention Methods: Pregnant women with cardiac disease attending antenatal clinic were studied over one year to assess their profiles and maternal and foetal outcome of pregnancy with women having corrective surgeries is evaluated. Results: Majority of women belong to ...

OBJECTIVE To evaluate how the implementation of universally acceptable standards affects rates for primary caesarean sections, without compromising maternal or foetal safety. METHODS A complete audit cycle of all the primary caesarean sections performed in the maternity unit of Aga Khan University was conducted from 1st January to 31st March during years 2003 and 2004. New labour management g...

PART I WITH improvements in maternal obstetric management, it is possible to turn increasingly to the care of the child, especially throughout labour and in the immediate postnatal period, when the child is at greatest risk. Though the signs considered to indicate foetal distress have been recognized for many years, it is, however, also necessary to assess the urgency and the severity of the th...

Objective : To evaluate the application and accuracy of foetal kidney length measurement in determining the gestational age of the foetus. Design : Prospective study Methodology : Out of 70 women, 50 women who were certain of their last menstrual periods (LMP) and who had regular menstrual cycle completed the study. Serial study of foetal biometry at 2 weekly intervals between 22 weeks and 38 w...

In I90I Ballantyne's ' Plea for a promaternity hospital' led to the first establishment of hospital beds for the specific purpose of studying the physiology and pathology of pregnancy. Although he quickly realized and strongly urged. the value of antenatal care to the mother, Ballantyne's original aim was chiefly to discover means of saving foetal life ' to prevent miscarriage and that most ter...

In summary, foetal and placental metabolisms have certain characteristics which appear to bridge species differences. The consumption of carbohydrate and amino acids by the foetal lamb is adequate to meet the energy, C and N requirements of the foetus both for oxidated metabolism and for growth. Techniques to study foetal or maternal metabolism or both under conditions of a biological steady st...

One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at E12.5, the embryo contains only a few definitive HSCs. It is thought that the burst of HSC activity in the foetal liver is underpinned by rapid maturation of immature embryonic precursors of definitive HSCs, termed pre-HSCs. However, because pre-HSCs are not detectable by direct transplantations into adul...