Macrophage-derived foam cells are a major component of atherosclerotic plaques and have an important role in the progression of atherosclerotic plaques, thus posing a great threat to human health. Photodynamic therapy (PDT) has emerged as a therapeutic strategy for atherosclerosis. Here, we investigated the effect of PDT mediated by upconversion fluorescent nanoparticles encapsulating chlorin e...

The synthesis of lipid by rabbit atherosclerotic intima incubated in vitro has been investigated and compared with that of foam cells isolated from intima] lesions. In the atherosclerotic arterial intima, C-labeled acetate is readily incorporated into the lipid fraction, most of the label being found in the phospholipid and cholesterol ester fatty acid fractions. Minimal incorporation into trig...

Macrophage foam cells are integral in the development of atherosclerotic lesions, however gene expression studies are complicated by the cellular heterogeneity of atherosclerotic plaque. This application note describes a protocol for LCM of cells identifi ed immunohistochemically, followed by realtime RT-PCR to selectively analyze RNA from foam cells of apolipoprotein E-defi cient mice. The spe...

Polyurethane-immobilized Flavobacterium cells (ATCC 39723) degraded pentachlorophenol (PCP) at initial concentrations as high as 300 mg liter-1. The reversible binding of PCP to the polyurethane was shown to be important in the protection of the cells from inhibition of PCP degradation. The degradation activity of the bacteria was monitored for 150 days in semicontinuous batch reactors. The deg...

foam injection is widely applied in amounts of fields to drilling, production, and formation protection. sometimes, the application result is disappointing, which is caused by the failure of bubble generation in foam flooding. therefore, it is necessary to seek ways for improving the performance of foam injection. an increased disturbance to the stratum, like the vibration caused by a seismic o...

RATIONALE LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoietic cells and immune responses. Macrophages transform into foam cells upon taking-in lipids. No role for LKB1 in foam cell formation has previously been reported. OBJECTIVE We sought to establish the role of LKB1 in atherosclerotic foam cell formation. METHODS AND...

This study demonstrates the growth and differentiation of C2C12 myoblasts into functional myotubes on 3-dimensional graphene foam bioscaffolds. Specifically, we establish both bare and laminin coated graphene foam as a biocompatible platform for muscle cells and identify that electrical coupling stimulates cell activity. Cell differentiation and functionality is determined by the expression of ...

Background: Holothuroids (sea cucumbers) are members of the phylum echinodermata, which produce saponins. Saponins exhibit a wide spectrum of pharmacological and biological activities. In this study, we isolated the crude saponins from the body wall of the dominant Iranian species of sea cucumber, Holothuria leucospilota (H. leucospilota). The purpose of this study was to confirm the presence o...

Auxetic materials or with a negative Poisson's ratio have great potential to be used in many industries because of their specific mechanical properties such as high stiffness and strength significant weight saving. In this article, the effect various parameters fabrication process on microstructure polyurethane auxetic foam was investigated. Moreover, compression behavior different situations, ...

The choice of foaming agent and its mass fraction significantly affect the size number metal foam cells. powder metallurgy process was used to produce aluminium foams with addition various agents: titanium hydride (TiH2) calcium carbonate (CaCO3). TiH2 added in an amount 0.4 wt.%, while quantity CaCO3 varied between 3 5 wt.%. produced foams, approximately same degree porosity, were scanned usin...