BACKGROUND Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action. RESULTS A new series of thioureas were synthesized. Fluorinated pyridine derivative 4a showed the highest antimicrobial activity (with MIC values ranged from 1.95 to 15.63 µg/mL). Interestingly, th...

A series of 18 samples has been prepared in order to obtain fluorinated materials as Protic Ionic Liquids (PILs). These were synthesized by appropriately mixing 1,2,4-oxadiazoles derivatised with two pyridines, or one pyridine and a fluorinated chain, and perfluoroalkyl-carboxylic acids, either mono- or dicarboxylic, leading to symmetric and non-symmetric materials. Many of them showed low melt...

In the automotive industry, introduction of alternative fuels in market or even consideration new fluids such as lubricants requires continuous efforts research and development to predict evaluate impacts on materials (e.g., polymers) contact with these fluids. We address here compatibility between polymers by means both experimental modelling techniques. Three were considered: a nitrile butadi...

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are a class of fluorinated organic chemicals containing at least one fully fluorinated carbon atom. The C-F bond is one of the strongest known covalent bonds, and the multiple C-F bonds in PFASs impart their chemical and thermal stability. The strength of the C-F bond arises, in part, from the electronegativity of the fluorine atom and from ...

Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence of fluorotyrosine may result in an improvement of the biological properties of this lipopeptide. The fluorinated iturin might also be used as a probe for studying its interacti...

Using plasma in conjunction with fluorinated compounds is widely encountered in material processing. We discuss several plasma techniques for surface fluorination: deposition of fluorocarbon thin films either by magnetron sputtering of polytetrafluoroethylene targets, or by plasma-assisted chemical vapor deposition using tetrafluoroethane as a precursor, and modification of carbon nanowalls by ...

We synthesized a series of fluorinated compounds and tested them in an easy assay for their repellent activity against the ant Myrmica rubra. Depending on their chain length and pattern of fluorination these molecules are efficient repellents for this ant. Fluorinated compounds are stronger repellents than their unfluorinated analogs. 1,1,1-Trifluorotridecan-2-one (4) is an even better repellen...

The presence of surface dipoles in selfassembled monolayers (SAMs) gives rise to profound effects on the interfacial properties of the films. For example, CF3terminated alkanethiolate films are surprisingly more wettable toward polar contacting liquids than analogous hydrocarbon SAMs due to the fluorocarbon-to-hydrocarbon transition (CF3−CH2) at the interface (i.e., the presence of a strong “FC...

Successful modeling of plasmas used in materials processing depends on knowledge of a variety of collision cross sections and reaction rates, both within the plasma and at the surface. Electron-molecule collision cross sections are especially important, affecting both electron transport and the generation of reactive fragments by dissociation and ionization. Because the supply of cross section ...

Treatment of tuberculosis (TB) and the discovery of effective new anti-tubercular drugs are among the most urgent priorities in health organizations all over the world. In the present study, fluorinated analogs of some of the most important anti-TB agents such as p-aminosalicylic acid (PAS), thiacetazone and pyrazinamide were synthesized and tested against TB. The fluorinated analog of thiaceta...