BACKGROUND We assessed the bioavailability of orange juice (poly)phenols by monitoring urinary flavanone metabolites and ring fission catabolites produced by the action of the colonic microbiota. OBJECTIVE Our objective was to identify and quantify metabolites and catabolites excreted in urine 0-24 h after the acute ingestion of a (poly)phenol-rich orange juice by 12 volunteers. DESIGN Twel...

Naturally multifunctional Rutaceae hesperidin and its aglycone hesperetin have a great variety of biopharmaceutical activities, e.g. anti-cancer, anti-inflammatory, antioxidant and antitumor; however, the influence of the molecular structures of hesperidin and hesperetin, and in particular, the structural properties such as flexibility and dynamic features of protein on the biological activitie...

There is evidence that many plant secondary metabolites may act as signal molecules to trigger the bacterial ability to metabolize polychlorinated biphenyls (PCBs) during the rhizoremediation process. However, the bases for the PCB rhizoremediation process are still largely unknown. The rhizobacterium Rhodococcus erythropolis U23A is unable to use flavanone as a growth substrate. However, on th...

A key step in the biosynthesis of flavonoids is the hydroxylation of (2s)-flavanones in the 3 position to form the respective dihydroflavonols. The reaction is catalyzed by F30H, a soluble fraction enzyme requiring 2-oxoglutarate, oxygen, Fez+, and ascorbate for full activity (Heller and Forkmann, 1988). By using genetic mutants that lack F 3 0 H activity, cDNA clones have been identified that ...

A nova “(-)-7,8,3’,4’-tri-hidróxi-8-(3’’,7’’-dimetil-octa-2’’,6’’-dienoil)-flavanona foi isolada a partir do extrato etanólico das raízes de Harpalyce brasiliana, juntamente com os pterocarpanos conhecidos (-)-2-geranil-3-hidróxi-8,9-metilenodioxipterocarpano, harpalicina, medicarpina, maackiaina e as cabenegrinas A-I e A-II. Os metabólitos isolados foram caracterizados com base nos seus dados ...

Discovering and developing drugs to treat Alzheimer's disease (AD) have been a crucial target for many decades. According large number of later studies, acetylcholinesterase (AChE) plays an important role in AD treatment. On the other hand, flavonoids are natural compounds that possessed wide variety bioactivities, including inhibitory activity on AChE. In this study, we reported structure rela...