Remyelination in the CNS: from biology to therapy. This finding confirms that remyelination must be a major therapeutic target in MS and the inherited human myelin disorders. 2008 Remyelination in the CNS: From biology to therapy. Masthead PDFIn stark contrast to the situation that follows loss of neurons or axonal damage, remyelination in the CNS can be a highly effective regenerative process....

We analyze a technique for unconstrained minimization without derivatives. This stems from two theorems proved by M. J. D. Powell. A particular version, which we consider in detail, is related to the Jacobi process for finding the eigensystem of a symmetric matrix, and the two processes, although different, help to illuminate one another. We study convergence of the search directions to mutual ...

Cloned code is one of the most important obstacles against consistent software maintenance and evolution. Although today’s clone detection tools find a variety of clones, they do not offer any advice how to remove such clones. We explain the problems involved in finding a sequence of changes for clone removal and suggest to view this problem as a process of stepwise unification of the clone ins...

Previously, we investigated the error-corrective properties of DNA. Although there is no evidence of a universal coding structure, we now show finite-field mathematics may yield a promising deterministic framework to analyze DNA. In this paper, we discuss a finite-field representation of nucleotides and explore an application, an algebraic technique for detecting near-periodic structure in DNA....

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell-specific transmembrane protein (...

The cause of Multiple sclerosis (MS) is unknown. Multiple theories for pathogenesis of MS postulated. The most accepted is autoimmune inflammatory process. In recent years the role of internal jugular vein abnormality in MS pathogenesis has been considered as “Big Idea” that raised hopes for MS treatment. But although the earlier studies were promising, their results were not reproducible and r...

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell– specific transmembrane protein ...