BACKGROUND Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a recombinant human IL-12 (rHuIL-12) is now under development to address the unmet need for a medical countermeasure against the hematopoietic syndrome of the acute radiation syndrome (HSARS) that occurs in individuals exposed t...

Objective: The study aimed to evaluate the critical physicochemical properties (lipophilicity, aqueous solubility, and degree of ionization) atractylodin β-eudesmol using in vitro testing.
 Methods: Lipophilicity (Log P Log D) was determined shake-flask method (n-octanol/water partition). Aqueous solubility kinetic assay media with pH ranging from 1.2 7.4. ionization (pKa) potentiometric t...