OBJECTIVE Despite numerous investigations, the question whether all bona fide treatments of depression are equally efficacious in adults has not been sufficiently answered. METHOD We applied two different meta-analytical techniques (conventional meta-analysis and mixed treatment comparisons). Overall, 53 studies with 3,965 patients, which directly compared two or more bona fide psychotherapie...

Although engineered nucleases can efficiently cleave intracellular DNA at desired target sites, major concerns remain on potential 'off-target' cleavage that may occur throughout the genome. We developed an online tool: predicted report of genome-wide nuclease off-target sites (PROGNOS) that effectively identifies off-target sites. The initial bioinformatics algorithms in PROGNOS were validated...

This paper studies the population of chess players and the distribution of their performances measured by Elo ratings and by computer analysis of moves. Evidence that ratings have remained stable since the inception of the Elo system in the 1970’s is given in several forms: by showing that the population of strong players fits a simple logistic-curve model without inflation, by plotting players...

This paper examines the intricacies of digital revolution, a bona fide renaissance in Indian financial landscape, catalysing an unprecedented surge inclusivity. It delves into multilayered, complex mechanisms technology adoption country's banking sector, scrutinising its impact on broader ambition universal access. The comprehensive analysis, juxtaposed against global perspective, illuminates t...

Psychotherapy has been found to be an effective treatment of post-traumatic stress disorder (PTSD), but meta-analyses have yielded inconsistent results on relative efficacy of psychotherapies in the treatment of PTSD. The present meta-analysis controlled for potential confounds in previous PTSD meta-analyses by including only bona fide psychotherapies, avoiding categorization of psychotherapy t...

Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) catalyzes the incorporation of atmospheric CO(2) into ribulose 1,5-bisphosphate (RuBP). RuBisCOs are classified into four forms based on sequence similarity: forms I, II and III are bona fide RuBisCOs; form IV, also called the RuBisCO-like protein (RLP), lacks several of the substrate binding and catalytic residues and does not catalyze ...

Fingerprint-based biometric systems have experienced a large development in the past. In spite of many advantages, they are still vulnerable to attack presentations (APs). Therefore, task determining whether sample stems from live subject (i.e., bona fide) or an artificial replica is mandatory requirement which has recently received considerable attention. Nowadays, when materials for fabricati...