It is characterized by a broad clinical spectrum, varying from the more frequent solitary (monostatic) asymptomatic lesion to extensive and severe multifocal (polyostatic) lesions. The monostotic variant most commonly affects the ribs, femur and tibia of older children and young adults. The less frequent polyostotic type may be associated with endocrine abnormalities, skin hyperpigmentation and...

Native extracellular matrix (ECM) is a complex fibrous structure loaded with bioactive cues that affects the surrounding cells. A promising strategy to mimicking native tissue architecture for tissue engineering applications is to engineer fibrous scaffolds using electrospinning. By loading appropriate bioactive cues within these fibrous scaffolds, various cellular functions such as cell adhesi...

INTRODUCTION Mazabraud's syndrome is a rare but well-described disorder characterized by fibrous dysplasia in single or multiple bones associated with one or more soft-tissue myxomas. In this report, we describe what is, to the best of our knowledge, the first case involving an intra-osseous myxoma. This finding supports, and could provide new insight into, the pathological association between ...

is a male-female predilection of 2:1. It has been described as freely mobile, well circumscribed, and subcuticular. Although the clinical characteristics of fibrous hamartoma have been variably reported, it has unique microscopic features. All prior cases consistently report well-defined traversing bundles of dense fibrocollagenous tissue, immature loose-textured mesenchyme, and increased areas...

Chondromyxoid fibroma (CMF) is the least common benign cartilaginous tumor, comprising less than 0.5 to 1% of all skeletal neoplasms. This subject was a 16-year-old female with a three-year history of pain involving the distal femoral metaphysis. This case showed an unusual feature: it was intracortical in location. Radiologic differential diagnosis included metaphyseal fibrous defect, perioste...

Medial meatal fibrosis is a rare condition in which the medial portion of the external auditory canal is obliterated with fibrous tissue. We selected 4 cases of patients with medial meatal fibrosis with a history of recurrent otorrhea who underwent surgery during the years of 2012 and 2013, presenting the surgical results here. Physical examination showed an obliterated external auditory canal ...

OBJECTIVE To investigate the structural organization of the connective tissue in the corpus cavernosum (CC) adjacent to the fibrous plaque in Peyronie's disease (PD) using stereological and biochemical techniques, as most studies on PD have focused on the analysis of the fibrous plaque that forms in the tunica albuginea (TA). Because this fibrotic reaction is mediated by various inflammatory so...

The solitary fibrous tumor is traditionally associated with a mesothelial-lined surface. However, any organ with mesenchymal tissue has the potential for developing this tumor; therefore, it has been described in organs not associated with serosal surfaces. We report a case of solitary fibrous tumor of the parotid gland. Microscopically, the tumor showed a patternless arrangement of spindle cel...

Background Clinical studies that have measured plaque T2 times were mostly performed ex-vivo using a small number of plaques excised from different arterial locations and imaged at different field strength using a limited number of TEs. The Table shows that T2 measured in the lipidrich necrotic core (LRNC) was consistently shorter than T2 in fibrous tissue or in normal media, which showed simil...

Solitary fibrous tumours are rare mesenchymal soft tissue tumours arising from multiple sites in the body including the dura and the intracranial ventricles. These masses are grouped along with rare haemangiopericytomas which form about less than 0.4 % of all CNS tumours. Locally aggressive solitary fibrous tumours closely mimic other dural based tumours most likely meningiomas. We report a cas...