UNLABELLED Direct-acting fibrin(ogen)olytic agents such as plasmin have been proved to contain effective and safety thrombolytic potential. Unfortunately, plasmin is ineffective when administered by the intravenous route because it was neutralized by plasma antiplasmin. Direct-acting fibrin(ogen)olytic agents with resistance against antiplasmin will brighten the prospect of anti-thrombosis. As ...

Thrombosis is the cause of many cardiovascular syndromes and is a significant contributor to life-threatening diseases, such as myocardial infarction and stroke. Thrombus targeted imaging agents have the capability to provide molecular information about pathological clots, potentially improving detection, risk stratification, and therapy of thrombosis-related diseases. Nanocarriers are a promis...

BACKGROUND Recent data indicate that stretching forces cause a dramatic decrease in clot volume accompanied by gross conformational changes of fibrin structure. OBJECTIVE The present study attempts to characterize the lytic susceptibility of fibrin exposed to mechanical stress as a model for fibrin structures observed in vivo. METHODS AND RESULTS The relevance of stretched fibrin models was...

Plasma levels of a fast-acting plasminogen activator inhibitor (PAI), which neutralizes both tissue plasminogen activator (t-PA) and urokinase, are markedly increased in endotoxin-treated rabbits. The ability of this inhibitor to prevent the fibrinolysis that occurs after a thrombogenic stimulus was investigated in a rabbit model. Normal and endotoxin-treated male New Zealand rabbits were infus...

Abitract: Retrieval of a Thrombus Attached to a Cournand Needle • Upon completion of a carotid angiogram, a clot of platelets, leukocytes, erythrocytes and fibrin was found attached to a No. 18 gauge Cournand needle. The chance retrieval of this thrombus establishes the occurrence of thrombus formation on angiographic needles. Such thrombi could be the source of some post-angiographic infarctio...

The authors describe a 51-year-old man with chronic lymphocytic leukemia who presented with respiratory distress and then died suddenly while in hospital. Autopsy revealed pulmonary leukostasis and a large intracardiac mass containing mostly mature lymphocytes and fibrin. Although leukostasis and lymphocyte thrombi have been described (albeit rarely) in chronic lymphocytic leukemia, an intracar...

Breakdown Breakdown is a very common cause of endometrial bleeding, it is explained by continuous estrogen effect which is the origin of fibrin thrombi and because of this there is stromal condensation and epithelial metaplasia finally resulting in significant fragmentation. Because of these changes the breakdown can be confused with a stromal or and epithelial proliferation and as a good rule ...

Circulating neutrophil extracellular traps (NETs) resistant to t-PA have not been studied completely although NETs in thrombi may contribute tissue plasminogen activator (t-PA) resistance. This research intended elucidate whether circulating are associated with resistance and the underlying mechanism. The levels of were detected neutrophils, ischemic brain acute stroke (AIS) patients, transient...

OBJECTIVE Evaluating thrombi microstructure developed in central venous catheters using confocal and electron microscopy. METHOD An experimental, descriptive study carrying out a microstructural evaluation of venous thrombi developed in central venous catheters using Scanning Electron Microscopy and Confocal Laser Scanning Microscopy. RESULTS A total of 78 venous catheters were collected ov...