Gülten TAÇOY, Murat ÖZDEMIR, Yusuf TAVIL, Sedat TÜRKOGLU, Atiye ÇENGEL Gazi Üniversity Medical Faculty, Department of Cardiology, Ankara. SUMMARY Purpose: Afterload reduction decreases volume overload on the left ventricle in chronic asymptomatic aortic regurgitation (AR). In this prospective, randomized trial, we aimed to compare the effects of a 6-months long treatment with lisinopril versus ...

PURPOSE To investigate the extent to which clinicians avoid well-established drug-drug interactions that cause statin-induced myopathy. We hypothesised that clinicians would avoid combining erythromycin or verapamil/diltiazem respectively with atorvastatin or simvastatin. In patients with statin-fibrate combination therapy, we hypothesised that gemfibrozil was avoided to the preference of bezaf...

Antihypertensive treatment with dihydropyridines may be accompanied by sympathetic activation. Data on whether this is common to all compounds and similar in the various phases of treatment are not univocal, however. In 28 untreated essential hypertensives (age, 56.4+/-1.8 years; mean+/-SEM) finger blood pressure (BP, Finapres), heart rate (HR, ECG), plasma norepinephrine (NE, high-performance ...

AIMS Major guidelines recommend lowering systolic blood pressure (SBP) to <140 mmHg in all hypertensives, but evidence is missing whether this is beneficial in (i) uncomplicated hypertensives, (ii) grade 1 hypertensives, and (iii) elderly hypertensives. Providing this missing evidence is important to justify efforts and costs of aggressive therapy in all hypertensives. METHODS AND RESULTS Fel...