RhoA/Rho kinases (ROCK) play a critical role in vascular smooth muscle cell (VSMC) actin cytoskeleton organization, differentiation, and function and are implicated in the pathogenesis of cardiovascular disease. We have previously determined that an important step in the regulation of calcification is fetuin-A endocytosis, a process that is dependent on changes in the cytoskeleton, which, in tu...

Chemical analysis of the Water-rock interaction showed that hydrothermal altered rock contains large amount of fluoride. Considering that alteration has mainly occurred at the fractures’ cleavages, the aim of this paper is to investigate the change of the mineral composition between the cleavages and other parts of the granite surfaces. Scanning electron microscope with energy-dispersive spectr...

The ROCK-I serine/threonine protein kinase mediates the effects of RhoA to promote the formation of actin stress fibres and integrin-based focal adhesions. ROCK-I phosphorylates the unconventional G-protein RhoE on multiple N- and C-terminal sites. These phosphorylation events stabilise RhoE, which functions to antagonise RhoA-induced stress fibre assembly. Here, we provide a molecular explanat...

Nucleophosmin (NPM)/B23 has been implicated in the regulation of centrosome duplication. NPM/B23 localizes between two centrioles in the unduplicated centrosome. Upon phosphorylation on Thr(199) by cyclin-dependent kinase 2 (CDK2)/cyclin E, the majority of centrosomal NPM/B23 dissociates from centrosomes, but some NPM/B23 phosphorylated on Thr(199) remains at centrosomes. It has been shown that...

------------------------------------------------------Abstract---------------------------------------------------------Estimation of strength properties (uniaxial compressive and point load) from physical properties (density, porosity and rebound hardness) of shale rock type from Kogi State, Nigeria was investigated. The shale rock types were sampled and tested for their properties through in-s...

INTRODUCTION Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as "té de roca" (rock tea) but there is no scientific evidence about the effects of this plant. AIM To evaluate the spasmolytic effect of rock tea. METHODS We have studied the in vitro effect of a rock tea extract ...

Radioactive strontium (90Sr) is an important constituent of the complex wastes from past nuclear weapons production and has been stored in underground tanks at U.S. DOE sites (e.g., Hanford, WA). Using bulk and microfocused EXAFS spectroscopy, we examined temporal changes in solid-phase Sr speciation in kaolinite samples reacted for 1-369 d with high-pH, high ionic strength synthetic tank-waste...

The main objective of this study was to investigate the performance of a roadheader used for the excavation of Küçüksu Sewage Tunnel having a length of 1037.52 m. The tunnel is located in Anatolian part of Istanbul and constructed by STFA for Istanbul Water and Sewerage Administration (ISKI). Detailed statistical analysis showed that net advance rate of the roadheader is directly influenced by ...

Studies were performed to determine the unknown status of PKC and RhoA/ROCK in the phorbol 12,13-dibutyrate (PDBu)-stimulated state in the human internal anal sphincter (IAS) smooth muscle cells (SMCs). We determined the effects of PDBu (10(-7) M), the PKC activator, on PKCα and RhoA and ROCK II translocation in the human IAS SMCs. We used immunocytochemistry and fluorescence microcopy in the b...