OPIE, LIONEL H., JOHN R. EVANS, AND JOSEPH C. SHIPP. Effect of fasting on ,~$ucosc: and pa/r&ate metabolism of perfused rat hiart. Am. J. Fhysiol. 205(6) : I 20331208. I g63.mThe metabolism of glucose CT-Cl”, 5 mM, and palmitate I-(?~, 0.75 mM (complexed to o.j’:i;: albumin), was studied in isolated perfused hearts taken from three groups of rats: fed ad libitum, fasted overnight, or fasted 4 d...

Since creatinine excretion reflects a continuous loss of creatine and creatine phosphate, there is a need for creatine replacement, from the diet and/or by de novo synthesis. Creatine synthesis requires three amino acids, methionine, glycine, and arginine, and two enzymes, l-arginine:glycine amidinotransferase (AGAT), which produces guanidinoacetate acid (GAA), and guanidinoacetate methyltransf...

A number of studies have brought to light the fact that substitution of fructose for glucose as the sole carbohydrate in a diet results in a profound change in the metabolic behavior of an animal. Thus, the ability of the liver of a glucose-fed, diabetic rat to convert acetate carbon to fatty acids is considerably impaired (l), but when the glucose of the animal’s diet is replaced by fructose, ...

Rat cecal microflora from high- and low-fiber-fed animals hydrolyzed aflatoxin conjugates to metabolites indistinguishable from aflatoxin B1 and aflatoxin P1, but aflatoxicol was not a transformation product.

In a study of the rat intestinal P(i) transport system, an activator protein for rat Na/P(i) co-transport system (PiUS) was isolated and characterized. We also investigated the effects of restriction of vitamin D and P(i) (two of the most important physiological and pathophysiological regulators of P(i) absorption in the small intestine) on intestinal P(i) transport activity and the expression ...

Abstract Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed investigate comparative effects high fat, sucrose and salt-induced IR fatty acid transporter (FATP) glucose (GLUT4) in rats. Results Rats fed with salt diets developed impaired tolerance ( p > 0.05) hyperinsulinemia < ...

Arteriovenous glucose difference across the mammary gland of the lactating rat was used as an 'instantaneous' monitor of mammary glucose uptake. Plasma [glucose] and arteriovenous glucose difference varied according to whether Halothane, diethyl ether or sodium pentobarbitone anaesthesia was used. In pentobarbitone-treated rats a 60% glucose extraction in the fed state decreased to 5% after 18 ...

Compared with the normotensive Wistar-Kyoto rat, the spontaneously hypertensive rat exhibits exaggerated alterations in renal sympathetic nerve activity and excretory function during volume expansion (exaggerated natriuresis) and environmental stress (antinatriuresis). The borderline hypertensive rat is the first filial offspring of the spontaneously hypertensive rat and the Wistar-Kyoto rat an...

This study's purpose was to examine the influence of an altered activity level, via artificial rearing, on the contractile properties, myosin heavy chain phenotypes (MHC), and muscle fiber sizes of the developing rat tongue retractor musculature. Artificially reared rat pups were fed through a gastric cannula, eliminating nutritive suckling from postnatal day 4 to postnatal day 14. Rat pups wer...